Association between serum uric acid and depressive symptoms stratified by low-grade inflammation status
Open Access
- 14 October 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in Scientific Reports
- Vol. 11 (1), 1-7
- https://doi.org/10.1038/s41598-021-99312-x
Abstract
Despite increasing evidence for an association between circulating uric acid (UA) and depression, the directionality of this association remains unclear and is potentially moderated by low-grade inflammation. Thus, the present study aimed to investigate the cross-sectional association between serum UA concentration and depressive symptoms in Korean individuals with and without low-grade inflammation, as measured using serum high-specific C-reactive protein (hs-CRP) levels. The final study sample comprised 4188 participants, aged 19–79 years, from the Korea National Health and Nutrition Examination Study 2016. Data on serum uric acid (UA) concentrations, serum hs-CRP levels, Patient Health Questionnaire-9 (PHQ-9) scores, and relative covariates were retrieved. Negative binomial regression with adjustment for the complex sample design was used to analyze the associations. After adjusting for covariates, log-transformed serum UA concentrations and total PHQ-9 scores were positively associated (incidence rate ratio [IRR] = 1.34 [95% confidence interval [CI] = 1.09–1.66]) for participants without low-grade inflammation and inversely associated (IRR = 0.64 [95% CI = 0.45–0.92]) for participants with low-grade inflammation. In conclusion, the direction of the association between serum UA and depressive symptoms was the opposite in participants with and without low-grade inflammation. The study has the limitation of potential uncontrolled confounders.This publication has 45 references indexed in Scilit:
- Impulsivity is Associated with Uric Acid: Evidence from Humans and MiceBiological Psychiatry, 2013
- Association between Serum Uric Acid Levels and Sleep Variables: Results from the National Health and Nutrition Survey 2005–2008International Journal of Inflammation, 2012
- Serum uric acid levels and the clinical characteristics of depressionClinical Biochemistry, 2012
- A review on the oxidative and nitrosative stress (O&NS) pathways in major depression and their possible contribution to the (neuro)degenerative processes in that illnessProgress in Neuro-Psychopharmacology and Biological Psychiatry, 2011
- A Review on the Putative Association Between Beta-Blockers and DepressionHeart Failure Clinics, 2011
- Clinical correlation of alteration of endogenous antioxidant-uric acid level in major depressive disorderIndian Journal of Clinical Biochemistry, 2010
- Uric Acid: The Oxidant-Antioxidant ParadoxNucleosides, Nucleotides and Nucleic Acids, 2008
- Validation of the Patient Health Questionnaire-9 Korean version in the elderly population: the Ansan Geriatric studyComprehensive Psychiatry, 2008
- Coming of Age of C-Reactive ProteinJournal of the American College of Cardiology, 2003
- Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis.Proceedings of the National Academy of Sciences of the United States of America, 1981