Redox- and Enzyme-Responsive Macrospheres Gatekept by Polysaccharides for Controlled Release of Agrochemicals
- 21 September 2021
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Agricultural and Food Chemistry
- Vol. 69 (38), 11163-11170
- https://doi.org/10.1021/acs.jafc.1c01304
Abstract
Stimuli-responsive materials afford researchers an opportunity to synthesize controlled-release carriers with various potential applications, especially for reducing the abuse of chemical reagents in farmland soil. To enhance the efficiency of agrochemical utilization, redox- and enzyme-responsive macrospheres were prepared by self-assembling β-cyclodextrin-modified zeolite and ferrocenecarboxylic acid (FcA)-grafted carboxymethyl cellulose (CMC). Scanning electron microscopy and Brunauer–Emmett–Teller analysis revealed that pores of zeolite were sealed by the surface coupling of FcA-modified CMC via the formation of an inclusion complex. Salicylic acid (SA) was loaded as a model agrochemical. The release of SA from macrospheres could be triggered in the presence of hydrogen peroxide (oxidant) and cellulase (enzyme); and the corresponding release percentages, 85.2 and 80.4%, were much higher than those of the control sample without responsive groups in water (12.6%) after 12 h. A release kinetic study showed that cellulase could promote carrier dissolution more effectively than the oxidant. The results demonstrate that the dual-responsive macrospheres are promising as a smart and effective carrier for the controlled release of agrochemicals.Funding Information
- Natural Sciences and Engineering Research Council of Canada
- National Natural Science Foundation of China (22068006)
- Guangxi Key Laboratory of Petrochemical Resource Processing and Process Intensi???cation Technology, Guangxi University (2019Z003)
This publication has 42 references indexed in Scilit:
- Redox-Responsive Polymer Brushes Grafted from Polystyrene Nanoparticles by Means of Surface Initiated Atom Transfer Radical PolymerizationMacromolecules, 2012
- Effective Gene Delivery Using Stimulus-Responsive Catiomer Designed with Redox-Sensitive Disulfide and Acid-Labile Imine LinkersBiomacromolecules, 2012
- Enzyme-Responsive Intracellular Controlled Release Using Nanometric Silica Mesoporous Supports Capped with “Saccharides”ACS Nano, 2010
- In situ generation of sodium alginate/hydroxyapatite nanocomposite beads as drug-controlled release matricesActa Biomaterialia, 2010
- Ferrocene Functional Polymer Brushes on Indium Tin Oxide via Surface-Initiated Atom Transfer Radical PolymerizationLangmuir, 2009
- Enzyme Responsive Nanocontainers with Cyclodextrin Gatekeepers and Synergistic Effects in Release of GuestsJournal of the American Chemical Society, 2009
- Quaternary Ammonium β-Cyclodextrin Nanoparticles for Enhancing Doxorubicin Permeability across the In Vitro Blood−Brain BarrierBiomacromolecules, 2009
- Nonequilibrium thermodynamics of thiol/disulfide redox systems: A perspective on redox systems biologyFree Radical Biology & Medicine, 2008
- Solubilization and Controlled Release of a Hydrophobic Drug Using Novel Micelle-Forming ABC Triblock CopolymersBiomacromolecules, 2003
- Thermal decomposition of β-cyclodextrin inclusion complexes of ferrocene and their derivativesThermochimica Acta, 1995