Non-invasive acquisition of fetal ECG from the maternal xyphoid process: a feasibility study in pregnant sheep and a call for open data sets
- 25 January 2018
- journal article
- research article
- Published by IOP Publishing in Physiological Measurement
- Vol. 39 (3), 035005
- https://doi.org/10.1088/1361-6579/aaaaa4
Abstract
Objective: The utility of fetal heart rate (FHR) monitoring can only be achieved with an acquisition sampling rate that preserves the underlying physiological information on the millisecond time scale (1000 Hz rather than 4 Hz). For such acquisition, fetal ECG (fECG) is required, rather than the ultrasound to derive FHR. We tested one recently developed algorithm, SAVER, and two widely applied algorithms to extract fECG from a single channel maternal ECG signal recorded over the xyphoid process rather than the routine abdominal signal. Approach: At 126dG, ECG was attached to near-term ewe and fetal shoulders, manubrium and xyphoid processes (n=12). FECG served as the ground-truth to which the fetal ECG signal extracted from the simultaneously-acquired maternal ECG was compared. All fetuses were in good health during surgery (pH 7.29±0.03, pO2 33.2±8.4, pCO2 56.0±7.8, O2Sat 78.3±7.6, lactate 2.8±0.6, BE -0.3±2.4). Main result: In all animals, single lead fECG extraction algorithm could not extract fECG from the maternal ECG signal over the xyphoid process with the F1 less than 50%. Significance: The applied fECG extraction algorithms might be unsuitable for the maternal ECG signal over the xyphoid process, or the latter does not contain strong enough fECG signal, although the lead is near the mother's abdomen. Fetal sheep model is widely used to mimic various fetal conditions, yet ECG recordings in a public data set form are not available to test the predictive ability of fECG and FHR. We are making this data set openly available to other researchers to foster non-invasive fECG acquisition in this animal model.This publication has 18 references indexed in Scilit:
- Commentary: Computerised interpretation of fetal heart rate during labour (INFANT): a randomised controlled trialFrontiers in Physiology, 2017
- Computerised interpretation of fetal heart rate during labour (INFANT): a randomised controlled trialThe Lancet, 2017
- An open-source framework for stress-testing non-invasive foetal ECG extraction algorithmsPhysiological Measurement, 2016
- Instrumentation of Near-term Fetal Sheep for Multivariate Chronic Non-anesthetized RecordingsJournal of Visualized Experiments, 2015
- Does heart rate variability reflect the systemic inflammatory response in a fetal sheep model of lipopolysaccharide-induced sepsis?Physiological Measurement, 2015
- Sampling rate of heart rate variability impacts the ability to detect acidemia in ovine fetuses near-termFrontiers in Pediatrics, 2014
- Determination of fetal heart rate from abdominal signals: evaluation of beat-to-beat accuracy in relation to the direct fetal electrocardiogramBiomedizinische Technik/Biomedical Engineering, 2012
- PhysioBank, PhysioToolkit, and PhysioNetJournal of the American College of Cardiology, 2000
- Fetal ECG extraction from single-channel maternal ECG using singular value decompositionIEEE Transactions on Biomedical Engineering, 1997
- Variability analysis of fetal heart rate signals as obtained from abdominal electrocardiographic recordingsjpme, 1986