Incidence of Guillain-Barré Syndrome Is Not Associated with Influenza Vaccination in the Elderly
Open Access
- 31 July 2020
- Vol. 8 (3), 431
- https://doi.org/10.3390/vaccines8030431
Abstract
We aimed to analyze the incidence of Guillain-Barré syndrome (GBS) and its association with influenza vaccination (IV) in the elderly population. This study included 2470 patients hospitalized with GBS (G61.0) between 2014 and 2016 based on the Korean National Health Insurance Service (NHIS) claims data. We reviewed every medical claim in the 42 days preceding GBS diagnosis looking for precedent causes of GBS. To assess the relationship between IV and the development of GBS, data from the NHIS and the National Vaccination Registry were combined and analyzed. Using a self-controlled case series (SCCS) approach, we calculated the incidence rate ratio by setting the risk period as 42 days following vaccination. The annual background incidence of GBS was estimated at 4.15 per 100,000 persons. More than half of the patients with newly developed GBS had a previous infection or surgery. The incidence of GBS within 42 days of IV was estimated at 0.32 per 100,000 vaccinated persons. SCCS analysis showed that the risk of GBS was not significantly higher. While GBS can potentially develop from various infections, no association was found between GBS and IV. These results will contribute to developing an evidence-based vaccine policy that includes a clear causality assessment of adverse events.Keywords
Funding Information
- Korea Centers for Disease Control and Prevention (2018-E2402-00)
This publication has 31 references indexed in Scilit:
- Safety of Pandemic (H1N1) 2009 Monovalent Vaccines in Taiwan: A Self-Controlled Case Series StudyPLOS ONE, 2013
- Population Incidence of Guillain-Barré Syndrome: A Systematic Review and Meta-AnalysisNeuroepidemiology, 2011
- Safety of trivalent inactivated influenza vaccines in adults: Background for pandemic influenza vaccine safety monitoringVaccine, 2009
- Seasonal Influenza: An OverviewThe Journal of School Nursing, 2009
- The Epidemiology of Guillain-Barré Syndrome WorldwideNeuroepidemiology, 2008
- Investigation of the Temporal Association of Guillain-Barre Syndrome With Influenza Vaccine and Influenzalike Illness Using the United Kingdom General Practice Research DatabaseAmerican Journal of Epidemiology, 2008
- Guillain-Barré Syndrome and Preceding Infection with Campylobacter, Influenza and Epstein-Barr Virus in the General Practice Research DatabasePLOS ONE, 2007
- Influenza,CampylobacterandMycoplasmaInfections, and Hospital Admissions for Guillain-Barré Syndrome, EnglandEmerging Infectious Diseases, 2006
- Tutorial in biostatistics: the self‐controlled case series methodStatistics in Medicine, 2005