Discovering a Reliable Heat-Shock Factor-1 Inhibitor to Treat Human Cancers: Potential Opportunity for Phytochemists
Open Access
- 6 April 2018
- journal article
- research article
- Published by Frontiers Media SA in Frontiers in Oncology
- Vol. 8, 97
- https://doi.org/10.3389/fonc.2018.00097
Abstract
Heat-shock factor-1 (HSF-1) is an important transcription factor that regulates pathogenesis of many human diseases through its extensive transcriptional regulation. Especially, it shows pleiotropic effects in human cancer, and hence it has recently received increased attention of cancer researchers. After myriad investigations on HSF-1, the field has advanced to the phase where there is consensus that finding a potent and selective pharmacological inhibitor for this transcription factor will be a major break-through in the treatment of various human cancers. Presently, all reported inhibitors have their limitations, made evident at different stages of clinical trials. This brief account summarizes the advances with tested natural products as HSF-1 inhibitors and highlights the necessity of phytochemistry in this endeavor of discovering a potent pharmacological HSF-1 inhibitor.Funding Information
- National Institutes of Health (R21HL078796-02 and R01HL78796-02, 5RO1HL081734-09)
This publication has 39 references indexed in Scilit:
- HSF1 Drives a Transcriptional Program Distinct from Heat Shock to Support Highly Malignant Human CancersCell, 2012
- Heat Shock Transcription Factor Hsf1 Is Involved in Tumor Progression via Regulation of Hypoxia-Inducible Factor 1 and RNA-Binding Protein HuRMolecular and Cellular Biology, 2012
- High levels of nuclear heat-shock factor 1 (HSF1) are associated with poor prognosis in breast cancerProceedings of the National Academy of Sciences of the United States of America, 2011
- Forced Expression of Heat Shock Protein 27 (Hsp27) Reverses P-Glycoprotein (ABCB1)-mediated Drug Efflux and MDR1 Gene Expression in Adriamycin-resistant Human Breast Cancer CellsOnline Journal of Public Health Informatics, 2011
- Heat Shock Transcription Factor 1 Is a Key Determinant of HCC Development by Regulating Hepatic Steatosis and Metabolic SyndromeCell Metabolism, 2011
- Xenohormesis: health benefits from an eon of plant stress response evolutionCell Stress and Chaperones, 2010
- Hsp27 Protects Adenocarcinoma Cells from UV-Induced Apoptosis by Akt and p21-Dependent Pathways of SurvivalMolecular Cancer Research, 2010
- Modulation of Akt and ERK1/2 Pathways by Resveratrol in Chronic Myelogenous Leukemia (CML) Cells Results in the Downregulation of Hsp70PLOS ONE, 2010
- A novel HSP90 modulator with selective activity against thyroid cancers in vitroSurgery, 2009
- Heat Shock Factor 1 Is a Powerful Multifaceted Modifier of CarcinogenesisCell, 2007