Palladium-Catalyzed Intramolecular Cross-Coupling of Unactivated C(sp3)–H and C(sp2)–H Bonds
- 3 September 2021
- journal article
- research article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 23 (18), 7161-7165
- https://doi.org/10.1021/acs.orglett.1c02567
Abstract
Direct C–H/C–H coupling represents an appealing method for the construction of C–C bonds, and the cross-coupling of unactivated C(sp3)–H and C(sp2)–H bonds is challenging and remains to be investigated. We have developed the Pd-catalyzed intramolecular coupling of inert C(sp3)–H and C(sp2)–H bonds. The reaction proceeded by o-methyl oxime-directed aryl C(sp2)–H activation and subsequent alkyl C(sp3)–H cleavage, generating C(sp2),C(sp3)-palladacycles as the key intermediates. Dihydrobenzofurans and indanes were formed as the final products.Keywords
Funding Information
- National Natural Science Foundation of China (21971196)
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