Soluble IL-33 receptor predicts survival in acute kidney injury
Open Access
- 6 June 2022
- journal article
- Published by Aboutscience Srl in Journal of Circulating Biomarkers
- Vol. 11, 28-35
- https://doi.org/10.33393/jcb.2022.2386
Abstract
Introduction: The prediction of acute kidney injury (AKI)-related outcomes remains challenging. Herein we prospectively quantified soluble ST2 (sST2), the circulating isoform of the IL-33 receptor, in hospitalized patients with AKI. Methods: In-hospital subjects with AKI of various etiology were identified through the in-hospital AKI alert system of the Brandenburg University hospital. sST2 was measured within a maximum of 48 hours from the time of diagnosis of AKI. The following endpoints were defined: in-hospital death, dialysis, recovery of kidney function until demission. Results: In total, 151 individuals were included in the study. The in-hospital mortality was 16.6%, dialysis therapy became mandatory in 39.7%, no recovery of kidney function occurred in 27.8%. sST2 was significantly higher in nonsurvivors (p = 0.024) but did not differ in the two other endpoints. The level of sST2 increased significantly with the severity of AKI. Further differences were detected in subjects with heart insufficiency (lower sST2), and in patients that required ICU treatment, or ventilatory therapy, or vasopressors (all higher). Conclusions: The current study suggests sST2 as biomarker of “acute distress”: it predicts post-AKI survival and substantially increases in subjects with a higher degree of cumulative morbidity under acute circumstances (e.g., ICU therapy, vasopressor administration).Keywords
This publication has 42 references indexed in Scilit:
- Biomarkers Predict Progression of Acute Kidney Injury after Cardiac SurgeryJournal of the American Society of Nephrology, 2012
- Use of Electronic Results Reporting to Diagnose and Monitor AKI in Hospitalized PatientsClinical Journal of the American Society of Nephrology, 2012
- Diagnostic and Prognostic Stratification in the Emergency Department Using Urinary Biomarkers of Nephron Damage: A Multicenter Prospective Cohort StudyJournal of Invasive Cardiology, 2012
- Risk of Poor Outcomes with Novel and Traditional Biomarkers at Clinical AKI DiagnosisClinical Journal of the American Society of Nephrology, 2011
- IL-33 Exacerbates Acute Kidney InjuryJournal of the American Society of Nephrology, 2011
- Urinary neutrophil gelatinase-associated lipocalin distinguishes pre-renal from intrinsic renal failure and predicts outcomesKidney International, 2011
- Soluble ST2 plasma concentrations predict mortality in severe sepsisIntensive Care Medicine, 2010
- Molecular mimicry between IL‐33 and KSHV for attachment to chromatin through the H2A–H2B acidic pocketEMBO Reports, 2008
- A comparison of the RIFLE and AKIN criteria for acute kidney injury in critically ill patientsNephrology Dialysis Transplantation, 2008
- Definition and diagnostic criteria of refractory ascites and hepatorenal syndrome in cirrhosisJournal of Hepatology, 1996