RHIVDB: A Freely Accessible Database of HIV Amino Acid Sequences and Clinical Data of Infected Patients
Open Access
- 10 June 2021
- journal article
- research article
- Published by Frontiers Media SA in Frontiers in Genetics
Abstract
Human immunodeficiency virus (HIV) infection remains one of the most severe problems for humanity, particularly due to the development of HIV resistance. To evaluate an association between viral sequence data and drug combinations and to estimate an effect of a particular drug combination on the treatment results, collection of the most representative drug combinations used to cure HIV and the biological data on amino acid sequences of HIV proteins is essential. We have created a new, freely available web database containing 1,651 amino acid sequences of HIV structural proteins [reverse transcriptase (RT), protease (PR), integrase (IN), and envelope protein (ENV)], treatment history information, and CD4+ cell count and viral load data available by the user’s query. Additionally, the biological data on new HIV sequences and treatment data can be stored in the database by any user followed by an expert’s verification. The database is available on the web at http://www.way2drug.com/rhivdb.Funding Information
- Russian Science Foundation
This publication has 18 references indexed in Scilit:
- Anti-HIV Agents: Current Status and Recent TrendsTopics in Medicinal Chemistry, 2016
- Prediction of drug-resistance in HIV-1 subtype C based on protease sequences from ART naive and first-line treatment failures in North India using genotypic and docking analysisAntiviral Research, 2011
- Fast, scalable generation of high‐quality protein multiple sequence alignments using Clustal OmegaMolecular Systems Biology, 2011
- Rationale and Uses of a Public HIV Drug‐Resistance DatabaseThe Journal of Infectious Diseases, 2006
- Web Resources for HIV Type 1 Genotypic-Resistance Test InterpretationClinical Infectious Diseases, 2006
- Susceptibility to HIV/AIDS: An Individual Characteristic We Can Measure?Infection, 2005
- HIV sequence databases.2003
- Human immunodeficiency virus reverse transcriptase and protease sequence databaseNucleic Acids Research, 2003
- Dressed to kill? A review of why antiviral CD8 T lymphocytes fail to prevent progressive immunodeficiency in HIV-1 infectionBlood, 2001
- Complete nucleotide sequence of the AIDS virus, HTLV-IIINature, 1985