Background: The goal of this study was to investigate the performance of the humerus bone fixation with screws while treating humerus bone fracture. Methods: The 34 patients’ retrospective data was collected with 1 year of follow up. Humerus fractures were treated by humerus plate fixation in different hospitals and countries, including 26 males and 8 females, with the age range of 32 -74 years (mean 47.4 years). Clinical and radiological follow-ups were conducted at 1 month, 3 months, 6 months and 1 year after surgery to check the bone union and implant-related complications. Ten different plates were used for the treatment of fracture as per the fracture type. The patient's health status was evaluated by the American society of anesthesiologists grade and the visual analogue score (VAS) was also obtained. Results: The progressive decline in the VAS score showed positive results related to pain management. All patients receive continuous physiotherapy under the supervision of physiotherapists, which aids in faster recovery and mobilization. No biomechanical issue related to implant plate and screw loosening, corrosion, bend, or other factors was detected in our 34 patients. Out of 34 patients 91% were satisfied with no pain and the remaining 9% were unsatisfied due to pain. About 85% of patients were happy with aesthetic appearance and the rest 14% of patients were unhappy related to aesthetic appearance. Conclusions: Humerus plate fixation is feasible for the treatment of humerus fracture. The clinical outcomes and prognosis of patients are dependent on the accuracy of intraoperative reduction and surgical expertise.