Chronic Cytomegalovirus Infection and Inflammation Are Associated with Prevalent Frailty in Community‐Dwelling Older Women
- 4 May 2005
- journal article
- Published by Wiley in Journal of the American Geriatrics Society
- Vol. 53 (5), 747-754
- https://doi.org/10.1111/j.1532-5415.2005.53250.x
Abstract
Objectives: To evaluate the association between asymptomatic chronic cytomegalovirus (CMV) infection and the frailty syndrome and to assess whether inflammation modifies this association. Design: Cross‐sectional analysis. Setting: Women's Health and Aging Study I & II, Baltimore, Maryland. Participants: Seven hundred twenty‐four community‐dwelling women aged 70 to 79 with baseline measures of CMV, interleukin‐6 (IL‐6), and frailty status. Measurements: CMV serology and IL‐6 concentrations were measured using enzyme‐linked immunosorbent assay. Frailty status was based on previously validated criteria: unintentional weight loss, weak grip strength, exhaustion, slow walking speed, and low level of activity. Frail women had three or more of the five components, prefrail women had one or two components, and women who were not frail had none of the components. Multinomial logistic regression adjusted for potential confounders. Results: Eighty‐seven percent of women were CMV seropositive, an indication of chronic infection. CMV was associated with prevalent frailty, adjusting for age, smoking history, elevated body mass index, diabetes mellitus, and congestive heart failure (CMV frail adjusted odds ratio (AOR)=3.2, P=.03; CMV prefrail AOR=1.5, P=.18). IL‐6 interacted with CMV, significantly increasing the magnitude of this association (CMV positive and low IL‐6 frail AOR=1.5, P=.53; CMV positive and high IL‐6 frail AOR=20.3, P=.007; CMV positive and low IL‐6 prefrail AOR=0.9, P=.73; CMV positive and high IL‐6 prefrail AOR=5.5, P=.001). Conclusion: Chronic CMV infection is associated with prevalent frailty, a state with increased morbidity and mortality in older adults; inflammation enhances this effect. Further prospective studies are needed to establish a causal relationship between CMV, inflammation, and frailty.Keywords
This publication has 35 references indexed in Scilit:
- Risk of cytomegalovirus transmission by blood products to immunocompromised patients and means for reductionBritish Journal of Haematology, 2004
- Structured intervention in family caregivers of the demented elderly and changes in their immune functionPsychiatry and Clinical Neurosciences, 2003
- Change in Muscle Strength Explains Accelerated Decline of Physical Function in Older Women With High Interleukin‐6 Serum LevelsJournal of the American Geriatrics Society, 2002
- Expansions of peripheral blood CD8 T-lymphocyte subpopulations and an association with cytomegalovirus seropositivity in the elderly: the Swedish NONA immune studyExperimental Gerontology, 2002
- Association of tumour necrosis factor alpha and interleukin 6 levels with cytomegalovirus DNA detection and disease after renal transplantationJournal of Medical Virology, 2001
- Molecular Pathways in Virus-Induced Cytokine ProductionMicrobiology and Molecular Biology Reviews, 2001
- Resistance exercise decreases skeletal muscle tumor necrosis factor α in frail elderly humansThe FASEB Journal, 2001
- Human Cytomegalovirus Latency and Reactivation – A Delicate Balance between the Virus and Its Host’s Immune SystemIntervirology, 1999
- Subcutaneous Adipose Tissue Releases Interleukin-6, But Not Tumor Necrosis Factor- , in VivoJournal of Clinical Endocrinology & Metabolism, 1997
- “Mini-mental state”: A practical method for grading the cognitive state of patients for the clinicianJournal of Psychiatric Research, 1975