Genetics of Shoot Meristem and Shoot Regeneration
- 23 November 2021
- journal article
- review article
- Published by Annual Reviews in Annual Review of Genetics
- Vol. 55 (1), 661-681
- https://doi.org/10.1146/annurev-genet-071719-020439
Abstract
Plants exhibit remarkable lineage plasticity, allowing them to regenerate organs that differ from their respective origins. Such developmental plasticity is dependent on the activity of pluripotent founder cells or stem cells residing in meristems. At the shoot apical meristem (SAM), the constant flow of cells requires continuing cell specification governed by a complex genetic network, with the WUSCHEL transcription factor and phytohormone cytokinin at its core. In this review, I discuss some intriguing recent discoveries that expose new principles and mechanisms of patterning and cell specification acting both at the SAM and, prior to meristem organogenesis during shoot regeneration. I also highlight unanswered questions and future challenges in the study of SAM and meristem regeneration. Finally, I put forward a model describing stochastic events mediated by epigenetic factors to explain how the gene regulatory network might be initiated at the onset of shoot regeneration. Expected final online publication date for the Annual Review of Genetics, Volume 55 is November 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.Keywords
This publication has 143 references indexed in Scilit:
- Pattern reorganization occurs independently of cell division during Drosophila wing disc regeneration in situProceedings of the National Academy of Sciences of the United States of America, 2013
- ERECTA-Family Receptor Kinases Regulate Stem Cell Homeostasis via Buffering its Cytokinin Responsiveness in the Shoot Apical MeristemPlant and Cell Physiology, 2012
- Cytokinin signaling as a positional cue for patterning the apical–basal axis of the growing Arabidopsis shoot meristemProceedings of the National Academy of Sciences of the United States of America, 2012
- WUSCHEL protein movement mediates stem cell homeostasis in the Arabidopsis shoot apexGenes & Development, 2011
- Spatially selective hormonal control of RAP2.6L and ANAC071 transcription factors involved in tissue reunion in ArabidopsisProceedings of the National Academy of Sciences of the United States of America, 2011
- Auxin–Cytokinin Interaction Regulates Meristem DevelopmentMolecular Plant, 2011
- Multiple feedback loops through cytokinin signaling control stem cell number within the Arabidopsis shoot meristemProceedings of the National Academy of Sciences of the United States of America, 2009
- Slicing across Kingdoms: Regeneration in Plants and AnimalsCell, 2008
- WUSCHEL controls meristem function by direct regulation of cytokinin-inducible response regulatorsNature, 2005
- Positional information and the spatial pattern of cellular differentiationJournal of Theoretical Biology, 1969