Analysis of the Microbial Landscape of Infection Site and the Effectiveness of Antibiotic and Immunotherapy in Patients with Diabetic Foot
- 26 August 2020
- journal article
- Published by Publishing House OKI in Antibiotics and Chemotherapy
- Vol. 65 (5-6), 25-29
- https://doi.org/10.37489/0235-2990-2020-65-5-6-25-29
Abstract
The article analyses the results of the study of 169 strains of microorganisms obtained from wound discharge from 132 patients with diabetes mellitus. Staphylococcus spp. bacteria held a leading place among Gram-positive pathogens. Gram-negative pathogens — Escherichia coli, Pseudomonas aeruginosa, etc. — were found less frequently. All isolated cultures were sensitive to levofloxacin and moxifloxacin, and only Acinetobacter spp. (n=2) remained intact (in vitro) after the use of levofloxacin. The intra-arterial route of administration of levofloxacin (500 mg/day) in combination with polyoxidonium (12 mg/day) through a port was used in 16 patients with diabetic foot. In all clinical cases, positive dynamics was noted: subsiding of the inflammatory process, cleansing of the wound from a purulent-necrotic substrate, and early epithelialization of the wound was observed in patients with diabetic foot.Keywords
This publication has 5 references indexed in Scilit:
- Skin InfectionsPrimary Care: Clinics in Office Practice, 2018
- The use of fluoroquinolones in the treatment of skin infectionsExpert Opinion on Pharmacotherapy, 2004
- Kliniko-morfologicheskie kharakteristiki reparatsii tkaney u bol'nykh s sindromom diabeticheskoy stopyDiabetes mellitus, 2001
- Evidence-based antibiotic therapy of diabetic foot infectionsFEMS Immunology & Medical Microbiology, 1999
- Immune dysfunction in patients with diabetes mellitus (DM)FEMS Immunology & Medical Microbiology, 1999