Study of Heat Shock Proteins during Wound Healing

Abstract

热休克蛋白广泛存在于各种生物体内，当生物体受到外界环境刺激后会大量表达，帮助生物体维持细胞的稳态。近期研究表明，热休克蛋白在伤口愈合过程中有促进细胞迁移的功能，通过向动物注射热休克蛋白能加速伤口的愈合过程，并且在高血糖环境下不受到阻碍。本综述通过查阅近年来相关资料，将热休克蛋白与传统的生长因子做了对比，描述了热休克蛋白90的功能和信号通路，总结了热休克蛋白在治疗伤口愈合过程中的优势和面临的困境。为将来研究伤口愈合的新药提供思路。 Heat shock proteins are widely present in various organisms. When organisms are stimulated by the external environment, they are expressed in large amounts, helping the organisms maintain the homeostasis of the cells. Recent studies have shown that heat shock proteins have a function of promoting cell migration during wound healing. By injecting heat shock proteins into animals, the healing process of wounds can be accelerated and unobstructed in a hyperglycemic environment. This review compares heat shock proteins with traditional growth factors, describes the function and signaling pathways of heat shock protein 90, and summarizes the advantages and disadvantages of heat shock proteins in the treatment of wound healing, providing ideas for future research on new drugs for wound healing.