The article analyzes the main policy directions towards Tajikistan, neighboring countries of Central Asia and culturally related to the Tajiks of the Middle East towards Tajikistan. The civil war in Tajikistan between supporters of the country’s secular and religious paths of development (1992-1997) caused mixed attitudes and policies on the part of various state, political and religious circles in Afghanistan. However, after it became clear that the struggle between secular and Islamist forces in Tajikistan could destroy the country as such, the culturally and linguistically close to the Tajiks political elite of Afghanistan (B. Rabbani and A. Masood) and Iran (A. Rafsanjani) made significant efforts to end the civil war in Tajikistan as mediators and expressed interest in the sustainable development of Tajikistan. In the 2000s, Iran abandoned attempts to influence Tajik policy in order to promote the establishment of a religious state in Tajikistan, turning to cooperation with the secular Tajik authorities in the economic sphere. Important issues complicating relations between Uzbekistan and Kyrgyzstan and Tajikistan are the construction by Tajiks of large hydropower plants on mountain rivers, which Uzbekistan considers a threat to national security, and unresolved border disputes, which are a source of constant aggravation in Kyrgyz-Tajik. In general, Tajikistan has complex problems of various kinds with most of its neighbors (with Afghanistan - drug trafficking and Islamic influences, with Uzbekistan - water energy, with Kyrgyzstan - border), which prevent bilateral relations to reach a new level of quality.