Genetic variations underlying self-reported physical functioning: a review
- 12 November 2014
- journal article
- review article
- Published by Springer Science and Business Media LLC in Quality of Life Research
- Vol. 24 (5), 1163-1177
- https://doi.org/10.1007/s11136-014-0844-z
Abstract
Genetic associations with self-reported physical functioning (SPF) are less well-studied than genetic associations with performance-measured physical functioning (PPF). We review the literature on the associations of genetic variations on SPF. We provide an overview of SPF assessment, genetic contributions to SPF including heritability, effects of genetic variations and mutations, and effects of interventions on the gene–SPF relationship. We also aim to provide directions for future research.Keywords
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