Role of NLRP3 Inflammasome in Atherosclerosis and Aortic Aneurysm
Open Access
- 10 October 2019
- journal article
- Published by Japan College of Angiology in The Journal of Japanese College of Angiology
- Vol. 59 (10), 83-87
- https://doi.org/10.7133/jca.19-00022
Abstract
動脈硬化や心筋梗塞といった心血管疾患の病態において無菌性炎症の重要性が示されている。われわれは,心血管疾患発症の分子機構に無菌性炎症の惹起経路であるNLRP3インフラマソームが関与することを報告してきた。また最近,NLRP3インフラマソームを制御する新規E3リガーゼを同定した。本稿では,動脈硬化や大動脈瘤形成におけるNLRP3インフラマソームの役割とともに,NLRP3インフラマソームの翻訳後修飾による制御機構について概説する。This publication has 24 references indexed in Scilit:
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