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INTERLEUKIN 10, BODY MASS INDEX AND SERUM ALBUMIN IN CHRONIC KIDNEY DISEASE STAGE 5D PATIENTS

I. Dudar, V. Drijanska, E. Grigorjeva, J. Gonchar, E. Krasjuk
Ukrainian Journal of Nephrology and Dialysis pp 30-33; doi:10.31450/ukrjnd.4(40).2013.04

Abstract: IL-10 - one of the central factors in the altered cytokine network of uremia, may play important role in the development of T-helper imbalance, CVD and wasting in dialysis patients. Aim: to evaluate level of ІL-10 in CKD stage 5D patients depending on the body mass index and serum albumin. Methods: Thirty-nine HD patients were included (male/female 20/19, age 21- 53 years, mean dialysis treatment time 4.2 ± 1.21 years). Blood tests were taken before a midweek dialysis session. Serum IL-10, serum albumin and BMI were measured. Results: HD patients had higher serum IL-10 than healthy donors (79.9 ± 7.3 vs. 18.8 ± 1.3 pg/ml, p < 0.001). Patients with low BMI had lower serum IL-10 than patients with normal BMI and large BMI – 31.0 ± 6.3 pg/ml; 76.7 ± 10.1 pg/ml; 117.7 ± 6.2 pg/ml, respectively (p < 0.001). Higher IL-10 was associated with increased serum albumin. Conclusion: Compensative increase of anti-inflammatory cytokine IL-10 in serum is typical in HD patients. Patients with nutrition deficit are characterized by lower serum IL-10.
Keywords: Treatment / BMI / chronic kidney disease / dialysis / serum albumin / pg/ml / HD patients

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