Antenatal corticosteroid treatment for the prevention of peri-intraventricular haemorrhage in preterm newborns: a retrospective cohort study using transfontanelle ultrasonography
Open Access
- 30 June 2017
- journal article
- Published by Medical Communications Sp. z.o.o. in Journal of Ultrasonography
- Vol. 17 (69), 91-95
- https://doi.org/10.15557/JoU.2017.0012
Abstract
The objective of this study was to assess the correlation between antenatal corticosteroids and peri-intraventricular haemorrhage (PIVH) using transfontanelle ultrasonography, as well as to evaluate the risk factors for its incidence. We performed a retrospective cohort study using medical records of preterm newborns. The protocol for maternal corticoid administration for foetal lung maturation included dexamethasone 4 mg (intramuscular) 8/8 hours per 48 hours, with one cycle per week. The diagnosis of periintraventricular haemorrhage was based on transfontanelle ultrasonography, using the Papile’s classification. The following risk factors for peri-intraventricular haemorrhage were assessed: birth weight, gestational age at delivery, type of delivery, newborn’s sex, surfactant administration, premature rupture of membranes and previous history of infection during the current pregnancy. The student’s t-test and chi-square test were used for statistical analysis. Our sample population included 184 preterm newborns. Transfontanelle ultrasonography revealed peri-intraventricular haemorrhage in 32 (74.4%) and periventricular leukomalacia in 11 (25.6%) newborns. Grade I haemorrhage was found in 20 (62.5%), grade II in five (15.6%), and grade III in seven (21.8%) newborns, as in accordance with Papile’s classification. Vaginal delivery (p = 0.010), birth weight <1500 g (p = 0.024), gestational age at delivery ≤32 weeks (p = 0.018), and previous history of infection during pregnancy (p = 0.013) were considered risk factors for peri-intraventricular haemorrhage in preterm newborns. Maternal corticoid administration for foetal lung maturation showed a protective effect against peri-intraventricular haemorrhage in preterm newborns. The risk factors for peri-intraventricular haemorrhage were determined.Keywords
This publication has 17 references indexed in Scilit:
- Second stage of labor and intraventricular hemorrhage in early preterm infants in the vertex presentationThe Journal of Maternal-Fetal & Neonatal Medicine, 2013
- Intraventricular Hemorrhage in Premature Infants: Mechanism of DiseasePediatric Research, 2010
- Severe Intraventricular Hemorrhage in Preterm Infants: Comparison of Risk Factors and Short-Term Neonatal Morbidities between Grade 3 and Grade 4 Intraventricular HemorrhageAmerican Journal of Perinatology, 2009
- Variable interpretation of ultrasonograms may contribute to variation in the reported incidence of white matter damage between newborn intensive care units in New ZealandArchives of Disease in Childhood: Fetal & Neonatal, 2005
- Achados ultra-sonográficos da hemorragia intracraniana em recém-nascidos prematurosArquivos de Neuro-Psiquiatria, 2005
- Improved Survival Rates With Increased Neurodevelopmental Disability for Extremely Low Birth Weight Infants in the 1990sPEDIATRICS, 2005
- Intraventricular haemorrhage and periventricular leukomalacia in Nigerian infants of very low birth weightWest Africa Journal of Medicine, 2004
- [Periventricular and intraventricular hemorrhage in the premature infants].2000
- Intraventricular hemorrhage in the preterm infantEarly Human Development, 1996
- RELIABILITY OF INTERPRETATION OF CRANIAL ULTRASOUND EXAMINATIONS OF VERY LOW-BIRTHWEIGHT NEONATESDevelopmental Medicine and Child Neurology, 1993