Experimental Periodontitis Deteriorates Cognitive Function and Impairs Insulin Signaling in a Streptozotocin-Induced Alzheimer’s Disease Rat Model
- 28 June 2022
- journal article
- research article
- Published by IOS Press in Journal of Alzheimer's Disease
- Vol. 88 (1), 57-74
- https://doi.org/10.3233/jad-215720
Abstract
Background: With advancements in periodontal medicine, the relationship between periodontitis and systemic diseases has garnered increasing attention. Recently, emerging evidence has indicated that periodontitis may be involved in the pathogenesis ofThis publication has 60 references indexed in Scilit:
- Role of Neuroinflammation in Adult Neurogenesis and Alzheimer Disease: Therapeutic ApproachesMediators of Inflammation, 2013
- In Vivo Cross-sectional Characterization of Cerebral Alterations Induced by Intracerebroventricular Administration of StreptozotocinPLOS ONE, 2012
- Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive declineJCI Insight, 2012
- Anti-tumor necrosis factor therapy improves insulin resistance, beta cell function and insulin signaling in active rheumatoid arthritis patients with high insulin resistanceArthritis Research & Therapy, 2012
- The novel object recognition memory: neurobiology, test procedure, and its modificationsCognitive Processing, 2011
- Dysregulation of Insulin Signaling, Glucose Transporters, O-GlcNAcylation, and Phosphorylation of Tau and Neurofilaments in the Brain: Implication for Alzheimer’s DiseaseThe American Journal of Pathology, 2009
- Improved method for combination of immunocytochemistry and Nissl stainingJournal of Neuroscience Methods, 2009
- Periodontitis is associated with cognitive impairment among older adults: analysis of NHANES-IIIJournal of Neurology, Neurosurgery & Psychiatry, 2009
- Inflammation and insulin resistanceJCI Insight, 2006
- Site-specific Phosphorylation and Caspase Cleavage Differentially Impact Tau-Microtubule Interactions and Tau AggregationOnline Journal of Public Health Informatics, 2006