Background: The development of blood clots (thrombi) in the deep veins is known as deep vein thrombosis (DVT). It frequently affects the deep pelvic veins or the deep leg veins (such as the calf veins, femoral vein, or popliteal vein). It is a potentially fatal condition that may result in morbidity and mortality that can be prevented. Aim was to assess the effectiveness of thrombectomy in treating patients with DVT. Methods: The 196 patients with DVT reporting to VKP’s VJ hospital, Tirunelveli, Tamil Nadu, were selected for this retrospective study. Thrombectomy was chosen as the treatment modality in this study. Results: Most patients were in the age group between 41 to 60 years (59.5%), with male predominance noted (77.4%). Pain and swelling are the most typical clinical features, 64.6% of patients presented with this sign. In patients with chronic and sub-acute DVT, 25% and 10.2% had residual thrombus visualized in doppler. Late complication, varicose veins were seen higher in patients with common iliac vein thrombosis (2/3) 66.7%, 52.6% (10/19) in external iliac vein thrombosis and 34.8% (8/23) in popliteal vein thrombosis. Late complication recurrence was seen higher in patients with partial occlusion (5/14) 35.7%, 21.4% (3/14) had varicose veins. Conclusions: The best course of treatment for DVT patients is thrombectomy, which can restore venous patency, stop DVT from returning, alleviate PTS, and prevent pulmonary embolism.