The article is devoted to the study of the state of homeostasis systems in patients with infectious eczema and the establishment of the relationship of the hemostatic system and immune status in the patient’s body. Examination of 108 patients with infectious eczema aged 18 to 65 years living in the southern region of Ukraine showed hypercoagulation changes in the hemostatic system and immune imbalance, which depend on the severity of the disease and play an important pathogenetic role in the onset and progression of this pathology. We have established close pathogenetic mechanisms of the relationship between the immune system and the hemostatic system (changes in the vascular-platelet link are associated with changes in humoral immunity – the content of, circulating immune complexes IgE), and coagulation hemostasis disorders – with indicators of cellular immunity (CD3 +, CD4 +, CD8 +, immunoregulatory index). Identified violations of hemostasis and immune status indicate the need to develop a pathogenetically substantiated method of complex individualized therapy for patients with infectious eczema.