Resilience Through Squamous Cell Carcinoma and Rhabdomyosarcoma of Oral Cavity: A Unique Case Report
Open Access
- 1 January 2016
- journal article
- Published by Elmer Press, Inc. in World Journal of Oncology
- Vol. 7 (4), 85-90
- https://doi.org/10.14740/wjon978w
Abstract
Rhabdomyosarcoma (RMS) is a soft tissue neoplasm of mesenchymal origin. It is a commonly encountered malignant tumor amongst pediatric patients, yet relatively rare in adults. It usually involves the head and neck region, genitourinary organs and retroperitoneal structures. In adults, the most commonly affected area is the head and neck region. We present here a case of a 30-year-old male patient with a primary squamous cell carcinoma of the tongue (T1, N0, M1), successfully cured with surgery and chemoradiotherapy and later on development of metachronous ipsilateral lesion on the left lower alveolus. Biopsy was consistent with spindle cell RMS. Immunohistochemistry demonstrated positivity for desmin, vimentin and myogenin, thus confirming the mesenchymal origin. With the best of our literature search, this is an exceptional case presenting two malignant lesions with diverse genetic origins, diagnosed at stage 1 and giving a favorable outcome.Keywords
This publication has 22 references indexed in Scilit:
- Cancer statistics, 2016CA: A Cancer Journal for Clinicians, 2016
- MicroRNA expression and its implications for diagnosis and therapy of tongue squamous cell carcinomaJournal of Cellular and Molecular Medicine, 2015
- Rhabdomyosarcoma in adolescent and young adult patients: current perspectivesAdolescent Health, Medicine and Therapeutics, 2014
- Oral cavity and oropharyngeal squamous cell carcinoma in young adults: a review of the literatureRadiology and Oncology, 2014
- Immunohistochemical study of CD44s expression in oral squamous cell carcinoma-its correlation with prognostic parametersJournal of Oral and Maxillofacial Pathology, 2014
- Squamous Cell Carcinoma: Morphological & Topographical Spectrum: A Two Year AnalysisIndian Journal of Surgery, 2012
- Rhabdomyosarcoma of the Oral Cavity: A Case ReportEuropean Journal of Dentistry, 2011
- Clinicopathological parameters, recurrence, locoregional and distant metastasis in 115 T1-T2 oral squamous cell carcinoma patientsHead & Neck Oncology, 2010
- Metastasis of squamous cell carcinoma of the oral tongueCancer and Metastasis Reviews, 2007
- The Intergroup Rhabdomyosarcoma Study Group (IRSG): Major Lessons From the IRS-I Through IRS-IV Studies as Background for the Current IRS-V Treatment ProtocolsSarcoma, 2001