Advances in the Study of Microsatellite Instability and Clinical and Prognosis of Gastric Cancer

Abstract

胃癌中微卫星不稳定亚型是胃癌分型的一大类，其形成机制和分子学构成都有着独特的特征，日益增多的研究表明微卫星不稳定型胃癌及其亚型不管是在基因方面，表观遗传学方面，临床病理特征以及其与不同辅助治疗之间的预后都存在密切的关系。本文就微卫星不稳定的概念，形成及检测方法，与胃癌有关的发病机制，临床和病理特征及与预后有关的研究做一简单综述。 Microsatellite instability is a kind of classification subtype in gastric cancer and its formation mechanism and molecular structure have unique characteristics. A growing number of studies have shown that microsatellite instability and its subtypes have relationship with genetic, epigenetic, clinical pathologic features and the prognosis in different adjuvant therapy. In this paper, we will review the concept, formation and detection methods of microsatellite instability, and the relationship about pathogenesis, clinical and pathological characteristics of gastric cancer.