Curcumin-Loaded Nanocomposite Hydrogel Augments Functional Muscle Recovery and Shows Synergistic Effects with Post-Injury Treadmill Exercise in a Muscle Injury Model in Rats: An In Vitro and In Vivo Study
- 1 March 2023
- journal article
- research article
- Published by American Scientific Publishers in Science of Advanced Materials
- Vol. 15 (3), 386-391
- https://doi.org/10.1166/sam.2023.4451
Abstract
Herein, the synergistic healing activity of treadmill exercise and curcumin-delivering hydrogel was evaluated in a rat model of skeletal muscle injury. In Vitro experiments were utilized to characterize the filler material and the healing potential of the treatment strategy was investigated in a rat model of anterior tibialis muscle injury. Study showed excellent biocompatibility of the hydrogel system. In Vivo study showed that the developed hydrogel and treadmill sport regimen significantly augmented muscle function recovery as evidenced by histopathological analysis. Gene expression studies showed that tissue expression levels of NFK-B and collagen type 1 genes were significantly downregulated in the animals treated with curcumin-loaded hydrogels with and without exercise.Keywords
This publication has 27 references indexed in Scilit:
- Curcumin ameliorated myocardial infarction by inhibition of cardiotoxicity in the rat modelJournal of Cellular Biochemistry, 2019
- Curcumin in tissue engineering: A traditional remedy for modern medicineBioFactors, 2018
- In vitro and in vivo study of PCL/COLL wound dressing loaded with insulin-chitosan nanoparticles on cutaneous wound healing in rats modelInternational Journal of Biological Macromolecules, 2018
- Current Methods for Skeletal Muscle Tissue Repair and RegenerationBioMed Research International, 2018
- NF-κB, inflammation, immunity and cancer: coming of ageNature Reviews Immunology, 2018
- Hydrogel biomaterials and their therapeutic potential for muscle injuries and muscular dystrophiesJournal of The Royal Society Interface, 2018
- The single and synergistic effects of montmorillonite and curcumin-loaded chitosan microparticles incorporated onto poly(lactic acid) electrospun film on wound-healingJournal of Bioactive and Compatible Polymers, 2017
- Keratin Hydrogel EnhancesIn VivoSkeletal Muscle Function in a Rat Model of Volumetric Muscle LossTissue Engineering, Part A, 2017
- Passive and active exercise improve regeneration and muscle reinnervation after peripheral nerve injury in the ratMuscle & Nerve, 2011
- Pathogenesis of fibrosis: type 1 collagen and the skinJournal of Molecular Medicine, 1998