Effects of sex, tobacco smoking, and alcohol consumption osteoporosis development: Evidence from Taiwan biobank participants
Open Access
- 17 June 2021
- journal article
- research article
- Published by E.U. European Publishing in Tobacco Induced Diseases
- Vol. 19 (June), 1-8
- https://doi.org/10.18332/tid/136419
Abstract
INTRODUCTION Osteoporosis is major public health concern, but the long-term impacts of tobacco and alcohol consumption on its development are unclear. This study analyzed the relationship between tobacco and alcohol use and osteoporosis by using data from the Taiwan Biobank (TWB), established in 2012. METHODS Participants in TWB were included in our study, with a total of 18394 respondents included for analysis. To investigate the relationship between tobacco and alcohol use and osteoporosis, we surveyed their bone mineral density (BMD), consumption of tobacco and alcohol and other covariate data. RESULTS We found that participants in the tobacco smoking only group (OR=1.24; 95% CI: 1.08-1.42, p=0.003) and the group that both smoked and consumed alcohol (OR=1.39; 95% CI: 1.09-1.77, p=0.008) were more likely to develop osteoporosis than were participants who neither drank alcohol nor smoked. Menopause is strongly associated with osteoporosis in women, and we found that women who used alcohol or tobacco were not at a significantly higher risk than those in the reference group (tobacco only, OR=1.15; 95% CI: 0.86-1.53, p=0.345; both tobacco and alcohol, OR=0.61; 95% CI: 0.14-2.60, p=0.5040). However, men in these groups were at a significantly higher risk than the reference group (tobacco only, OR=1.26; 95% CI: 1.07-1.48, p=0.006; both tobacco and alcohol, OR=1.32; 95% CI: 1.03-1.70, p=0.030). Menopause was a significant risk factor for osteoporosis (OR=2.46; 95% CI: 1.77-3.41, p<0.001). CONCLUSIONS The influence of tobacco use on osteoporosis was significant, particularly in men, but the effects of alcohol consumption were equivocal in our study. The interactions between tobacco use, alcohol use, and menopausal status on osteoporosis should be considered in future studies.Keywords
This publication has 34 references indexed in Scilit:
- Osteoporosis, Fractures, and DiabetesInternational Journal of Endocrinology, 2014
- Postmenopausal Osteoporosis: The Role of Immune System CellsJournal of Immunology Research, 2013
- Moderate alcohol intake lowers biochemical markers of bone turnover in postmenopausal womenMenopause, 2012
- Osteoporosis and type 2 diabetes mellitus: what do we know, and what we can do?Patient Preference and Adherence, 2012
- Osteoporosis in diabetes mellitus: Possible cellular and molecular mechanismsWorld Journal of Diabetes, 2011
- Low level nicotine: A novel approach to reduce osteoporosis incidenceMedical Hypotheses, 2010
- Pathologic fractures correlate with reduced survival in patients with malignant bone diseaseCancer, 2007
- An approach for identifying postmenopausal women age 50–64 years at increased short-term risk for osteoporotic fractureOsteoporosis International, 2007
- Definition of OsteoporosisPublished by Springer Science and Business Media LLC ,2004
- Epidemiology and outcomes of osteoporotic fracturesThe Lancet, 2002