Enantioselective PCCP Brønsted Acid Catalyzed Aminalization of Aldehydes
Preprint
- 28 June 2021
- preprint
- Published by Beilstein Institut
- Vol. 2021 (1), 48
- https://doi.org/10.3762/bxiv.2021.48.v1
Abstract
Here we present an enantioselective aminalization of aldehydes catalyzed by Brønsted acids based on pentacarboxycyclopentadienes (PCCPs). Cyclization reaction using readily available anthranilamides as building-blocks provides an access to valuable 2,3-dihydroquinazolinones containing one stereogenic carbon center with high degree of enantioselectivities (ee up to 81 %) and excellent yields (up to 97%).Keywords
Other Versions
- Published version: Version Beilstein Journal of Organic Chemistry, 17, preprints