Background: The present study is anticipated the perspective of physico chemical characteristics of the traditional Siddha medicine Kodi pavala chunnam . It is a herbo mineral formulation which treats the Cholelithiasis & it's related symptoms. Materials and Methods: The drug was prepared as mentioned in the Siddha literature Noigaluku Siddha parigaaram part 2 .Then the prepared drug was undergone physicochemical, biochemical, organoleptic and phytochemical analysis and HPTLC. Results: Loss on drying at 105°C was 0.8667 ± 0.4041,Total ash (%) was 55.67 ± 9.603,Acid insoluble ash (%) 0.64 ± 0.02,Water soluble extractive was 3.1 ± 1.044, Alcohol soluble extractive (%) was 0.2533 ± 0.0611, the PH was 8 which indicates alkaline nature of the drug. From the results the drug was free from microbial contamination . Heavy metals and Pesticide residues were below the quantification limit.Conclusion: The result shows that the drug is of standard quality and can be used as reference in laying pharmacopoeia standards. From the results obtained in the above investigations it was concluded that the drug is effective biologically active components which may helps in treating cholelithiasis and it's related ailments.