First trimester 3D ultrasound placental volume at 11th to 13th weeks gestational age for predicting preeclampsia

Abstract

Background: After the 20th week of pregnancy, preeclampsia is diagnosed when a woman develops new-onset hypertension (systolic blood pressure 140 mm Hg or higher, or diastolic blood pressure 90 mm Hg or higher) and proteinuria (300 mg or more in a 24-hour urine collection, or 1+ on dipstick testing). The aim of this work was to determine the sensitivity of placental volume (PV) in the first trimester at 11th week to 13th week+6 days in predicting preeclampsia. Methods: This prospective observational study was carried out on 250 women with any gravidity, singleton pregnancy between 11th to 13th week of gestation based on the last menstrual period or first-trimester ultrasound. All patients were subjected to laboratory investigations (CBC, Renal function tests, Random blood sugar and tests to detect proteinuria.) and imaging. Results: The sensitivity and specificity of PV in differentiating between preeclampsia and normotensive were 60.0%; 60.0% respectively. There was high significant difference in between preeclmpesia and normotensive cases regarding to PV. Conclusions: The PV was lower in cases with preeclampsia as compared to nonpreeclamptic women with highly significant statistical difference and that means 3D PV measurement at 11th to 13th week of pregnancy could increase the predictive accuracy for pre-eclampsia.