A subcritical water extract of soil grown Zingiber officinale Roscoe: Comparative analysis of antioxidant and anti-inflammatory effects and evaluation of bioactive metabolites
Open Access
- 8 February 2023
- journal article
- research article
- Published by Frontiers Media SA in Frontiers in Pharmacology
- Vol. 14, 1006265
- https://doi.org/10.3389/fphar.2023.1006265
Abstract
Ginger (Zingiber officinale Roscoe) can scavenge free radicals, which cause oxidative damage and inflamm-ageing. This study aimed to evaluate the antioxidant and anti-inflammatory effects of soil ginger's sub-critical water extracts (SWE) on different ages of Sprague Dawley (SD) rats. The antioxidant properties and yield of SWE of soil- and soilless-grown ginger (soil ginger and soilless ginger will be used throughout the passage) were compared and evaluated. Soil ginger was found to yield 46% more extract than soilless ginger. While [6]-shogaol was more prevalent in soilless ginger, and [6]-gingerol concentration was higher in soil ginger (p<0.05). Interestingly, soil ginger exhibited higher antioxidant activities than soilless ginger by using 2,2-diphenyl-1-(2,4,6-trinitrophenyl) hydrazyl (DPPH) and ferric reducing antioxidant power (FRAP) assay. Subsequently, three (young), nine (adult), and twenty-one (old) months old SD rats were subjected to oral gavage treatments with either distilled water or the SWE of soil ginger at a concentration of 200 mg/kg body weight (BW) for three months. With ginger treatment, a reduced levels of tumour necrosis factor-α (TNF-α) and C-reactive protein (CRP) but not interleukin-6 (IL-6) were observed in young rats. In all ages of SD rats, ginger treatment boosted catalase activity while lowering malondialdehyde (MDA). Reduction of urine 15-isoprostane F2t in young rats, creatine kinase-MM (CK-MM) in adult and old rats and lipid peroxidation (LPO) in young and adult rats were also observed. The findings confirmed that the SWE of both soil and soilless grown ginger possessed antioxidant activities. Soil ginger produced a higher yield of extracts with a more prominent antioxidant activity. The SWE of soil ginger treatment on the different ages of SD rats ameliorates oxidative stress and inflammation responses. This could serve as the basis for developing a nutraceutical that can be used as a therapeutic intervention for ageing-related diseases.This publication has 69 references indexed in Scilit:
- Black ginger extract increases physical fitness performance and muscular endurance by improving inflammation and energy metabolismHeliyon, 2016
- Myomir dysregulation and reactive oxygen species in aged human satellite cellsBiochemical and Biophysical Research Communications, 2016
- Comparison of different drying methods on Chinese ginger (Zingiber officinale Roscoe): Changes in volatiles, chemical profile, antioxidant properties, and microstructureFood Chemistry, 2016
- Ageing-Associated Oxidative Stress and Inflammation Are Alleviated by Products from GrapesOxidative Medicine and Cellular Longevity, 2016
- Ginger Supplementation in Nonalcoholic Fatty Liver Disease: A Randomized, Double-Blind, Placebo-Controlled Pilot StudyHepatitis Monthly, 2016
- Oxidative Stress, Inflammation, and DiseasePublished by Elsevier BV ,2016
- Urinary biomarkers of oxidative damage in Maple syrup urine disease: The l‐carnitine roleInternational Journal of Developmental Neuroscience, 2015
- Antioxidant activity by DPPH assay of potential solutions to be applied on bleached teethBrazilian Dental Journal, 2012
- Dichlorvos and lindane induced oxidative stress in rat brain: Protective effects of gingerPharmacognosy Research, 2012
- A Regulatory Effect of the Balance between TNF-α and IL-6 in the Granulomatous and Inflammatory Response to Rhodococcus aurantiacus Infection in MiceThe Journal of Immunology, 2006