Post-chemotherapy maintenance treatment by nicotinamide riboside, a poly ADP ribose polymerase 1 inhibitor, in BRCA mutated advanced ovarian cancer – A perspective
Open Access
- 6 August 2021
- journal article
- Published by Scientific Scholar in International Journal of Molecular and Immuno Oncology
- Vol. 6, 118-121
- https://doi.org/10.25259/ijmio_12_2021
Abstract
Poly ADP ribose polymerase 1 (PARP-1) inhibitors are approved for post-chemotherapy maintenance in BRCA mutated ovarian carcinoma. Various PARP-1 inhibitors such as olaparib, rucaparib, niraparib, and veliparib are approved for this indication. These PARP-1 inhibitors are costly as well as having toxic potential, anemia, and neutropenia is the major side effects. Most of the middle-aged women in Indian subcontinent are anemic and prescription of PARP-1 inhibitors is tricky in such conditions, besides their cost is at times unaffordable as maintenance chemotherapy. Hence, we need an affordable yet lesser toxic PARP-1 inhibitor to solve this problem. Nicotinamide, a vitamin B3 amide can be re-purposed as PARP-1 inhibitor. Nicotinamide, albeit at a higher dose, can be efficacious as well as economical in its use as maintenance chemotherapy. It has toxic potential but the toxicity is both rare and manageable. We need a clinical trial for this purpose. Following perspective is on the current evidence on high dose nicotinamide and it is re-purposing as PARP-1 inhibitor.Keywords
This publication has 28 references indexed in Scilit:
- Accelerated Radiotherapy With Carbogen and Nicotinamide for Laryngeal Cancer: Results of a Phase III Randomized TrialJournal of Clinical Oncology, 2012
- Oral Nicotinamide Reduces Actinic Keratoses in Phase II Double-Blinded Randomized Controlled TrialsJournal of Investigative Dermatology, 2012
- Evidence That Niacin Inhibits Acute Vascular Inflammation and Improves Endothelial Dysfunction Independent of Changes in Plasma LipidsArteriosclerosis, Thrombosis, and Vascular Biology, 2010
- Role of Nicotinamide in DNA Damage, Mutagenesis, and DNA RepairJournal of Nucleic Acids, 2010
- Poly(ADP-ribose) polymerase (PARP) inhibition or PARP-1 gene deletion reduces angiogenesisEuropean Journal of Cancer, 2007
- Carbogen and Nicotinamide Increase Blood Flow and 5-Fluorouracil Delivery but not 5-Fluorouracil Retention in Colorectal Cancer Metastases in PatientsClinical Cancer Research, 2006
- Nicotinamide is a potent inhibitor of proinflammatory cytokinesClinical and Experimental Immunology, 2003
- NICOTINAMIDE INHIBITS INDUCIBLE NITRIC OXIDE SYNTHASE ENZYME ACTIVITY IN MACROPHAGES BY ALLOWING NITRIC OXIDE TO INHIBIT ITS OWN FORMATIONLife Sciences, 1997
- A Population Based Strategy to Prevent Insulin-Dependent Diabetes Using NicotinamideJournal of Pediatric Endocrinology and Metabolism, 1996
- Inhibition of nuclear NAD nucleosidase and poly ADP-ribose polymerase activity from rat liver by nicotinamide and 5′-methyl nicotinamideBiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1971