A Recent Human Immunodeficiency Virus Outbreak Among People Who Inject Drugs in Munich, Germany, Is Associated With Consumption of Synthetic Cathinones
Open Access
- 27 May 2020
- journal article
- research article
- Published by Oxford University Press (OUP) in Open Forum Infectious Diseases
- Vol. 7 (6), ofaa192
- https://doi.org/10.1093/ofid/ofaa192
Abstract
Needle and syringe sharing among people who inject drugs (PWID) can result in a rapid regional spread of a Human Immunodeficiency Virus (HIV) variant. Such outbreaks have been identified recently in several countries and have raised public health attention because of an association with New Psychoactive Substances (NPS). Dried Serum Spots (DSS) from about 60% of newly diagnosed German HIV cases in 2013-2018 were received together with statutory notification data. Samples were sequenced in the pol-region, genotyped and viral phylogenies analyzed. For selected samples the Hepatitis C Virus (HCV) status and the presence of NPS were determined. An outbreak of closely related 27 subtype C infections with a core of 11 cases with almost identical sequences was identified using phylogenetic analyses. The first case of the outbreak was diagnosed in 2015, and the last one in 2018. With exception of three infections all were reported from Munich, the capital of the federal state of Bavaria. Of 26 analyzed outbreak members 24 (92.3%) had a resolved or viremic HCV co-infection. In 8/18 (44%) cases α-pyrrolidinopentiothiophenone (α–PVT) and/or the related substance α-pyrrolidinoheptiophenone (PV8) was identified. Despite harm reduction services in place HIV outbreaks of considerable size can occur in PWID. The establishment of a real time molecular surveillance is advised in order to rapidly identify outbreaks and target prevention measures.Funding Information
- German Federal Ministry of Health (ZMVI-2516AUK701)
- Bill & Melinda Gates Foundation (OPP1175094, OPP1084362)
This publication has 42 references indexed in Scilit:
- Homelessness and Other Risk Factors for HIV Infection in the Current Outbreak Among Injection Drug Users in Athens, GreeceAmerican Journal of Public Health, 2015
- Automated subtyping of HIV-1 genetic sequences for clinical and surveillance purposes: Performance evaluation of the new REGA version 3 and seven other toolsInfection, Genetics and Evolution, 2013
- Improving Bayesian Population Dynamics Inference: A Coalescent-Based Model for Multiple LociMolecular Biology and Evolution, 2012
- “A Costly Turn On”: Patterns of use and perceived consequences of mephedrone based head shop products amongst Irish injectorsInternational Journal of Drug Policy, 2012
- FLASH: fast length adjustment of short reads to improve genome assembliesBioinformatics, 2011
- Drug Resistance Mutations for Surveillance of Transmitted HIV-1 Drug-Resistance: 2009 UpdatePLOS ONE, 2009
- Intérêt d'un nouveau test combiné antigène–anticorps pour le dépistage de l'infection par le virus de l'hépatite C : réduction de la fenêtre sérologique au cours de l'hépatite C aiguë chez le sujet co-infecté par le VIHPathologie Biologie, 2006
- Web Resources for HIV Type 1 Genotypic-Resistance Test InterpretationClinical Infectious Diseases, 2006
- Évaluation de deux trousses commerciales EIA pour le diagnostic de l’hépatite C dans les conditions d’un laboratoire de virologiePathologie Biologie, 2004
- An HIV Type 1 Epidemic among Injecting Drug Users in the Former Soviet Union Caused by a Homogeneous Subtype A StrainAIDS Research and Human Retroviruses, 1997