All‐Optical and Label‐Free Stimulation of Action Potentials in Neurons and Cardiomyocytes by Plasmonic Porous Metamaterials
Open Access
- 5 September 2021
- journal article
- research article
- Published by Wiley in Advanced Science
- Vol. 8 (21), 2100627
- https://doi.org/10.1002/advs.202100627
Abstract
Optical stimulation technologies are gaining great consideration in cardiology, neuroscience studies, and drug discovery pathways by providing control over cell activity with high spatio-temporal resolution. However, this high precision requires manipulation of biological processes at genetic level concealing its development from broad scale application. Therefore, translating these technologies into tools for medical or pharmacological applications remains a challenge. Here, an all-optical nongenetic method for the modulation of electrogenic cells is introduced. It is demonstrated that plasmonic metamaterials can be used to elicit action potentials by converting near infrared laser pulses into stimulatory currents. The suggested approach allows for the stimulation of cardiomyocytes and neurons directly on commercial complementary metal-oxide semiconductor microelectrode arrays coupled with ultrafast pulsed laser, providing both stimulation and network-level recordings on the same device.Funding Information
- European Research Council
This publication has 47 references indexed in Scilit:
- Functional improvement and maturation of rat and human engineered heart tissue by chronic electrical stimulationJournal of Molecular and Cellular Cardiology, 2014
- Atrium-Specific Kir3.x Determines Inducibility, Dynamics, and Termination of Fibrillation by Regulating Restitution-Driven AlternansJournal of the American College of Cardiology, 2013
- Optogenetics and Translational MedicineScience Translational Medicine, 2013
- A polymer optoelectronic interface restores light sensitivity in blind rat retinasNature Photonics, 2013
- Microsystems for biomimetic stimulation of cardiac cellsLab on a Chip, 2012
- Stimulating Cardiac Muscle by LightCirculation: Arrhythmia and Electrophysiology, 2011
- Optogenetic Control of Cardiac FunctionScience, 2010
- Surface enhanced Raman scattering of nanoporous gold: Smaller pore sizes stronger enhancementsApplied Physics Letters, 2007
- Basic Mechanisms of Cardiac Impulse Propagation and Associated ArrhythmiasPhysiological Reviews, 2004
- Formation and maturation of synapses in primary cultures of rat cerebral cortical cells: an electron microscopic studyNeuroscience Research, 1993