Influence of Nonalcoholic Fatty Liver Disease on the Occurrence and Severity of Chronic Kidney Disease
Open Access
- 22 September 2021
- journal article
- review article
- Published by Xia & He Publishing in Journal of Clinical and Translational Hepatology
- Vol. 10 (1), 164-173
- https://doi.org/10.14218/jcth.2021.00171
Abstract
Nonalcoholic fatty liver disease (NAFLD) is reported to affect 20-30% of adults and is accompanied by various metabolic comorbidities, where the economic and clinical burden of NAFLD is attributed to the progression of liver disease as well as the presence of extrahepatic diseases. Chronic kidney disease (CKD), which has a high incidence rate, high morbidity and mortality rates, and high medical costs, has been linked to NAFLD. CKD is associated with some metabolism-related risk factors that overlap with metabolic comorbidities of NAFLD. Therefore, to investigate the potential factors that influence CKD occurrence, the association between NAFLD and CKD should be clarified. Some studies have confirmed that NAFLD influences the occurrence and severity of CKD, whereas some studies have indicated that there is no correlation. In this review, the results of a few studies have been discussed, the potential risk factors for CKD in NAFLD are explored, and the respective biological mechanisms are elaborated to help clinicians identify CKD in patients much earlier than it is diagnosed now and thus help in reducing the incidence of liver and kidney transplants.Keywords
This publication has 109 references indexed in Scilit:
- Chronic Kidney Disease and Nonalcoholic Fatty Liver Disease Proven by Transient ElastographyKidney and Blood Pressure Research, 2013
- Chronic kidney disease: global dimension and perspectivesThe Lancet, 2013
- Gut flora metabolism of phosphatidylcholine promotes cardiovascular diseaseNature, 2011
- Systematic review: the diagnosis and staging of non‐alcoholic fatty liver disease and non‐alcoholic steatohepatitisAlimentary Pharmacology & Therapeutics, 2010
- Relationship between Kidney Function and Liver Histology in Subjects with Nonalcoholic SteatohepatitisClinical Journal of the American Society of Nephrology, 2010
- A Stress Signaling Pathway in Adipose Tissue Regulates Hepatic Insulin ResistanceScience, 2008
- Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver diseaseNature Genetics, 2008
- Increased Risk of CKD among Type 2 Diabetics with Nonalcoholic Fatty Liver DiseaseJournal of the American Society of Nephrology, 2008
- Fetuin-A and kidney function in persons with coronary artery disease—data from the heart and soul studyNephrology Dialysis Transplantation, 2006
- Nonalcoholic Fatty Liver Disease: From Steatosis to CirrhosisJournal of Hepatology, 2006