Procalcitonin in Preterm Neonates: A Different Threshold and Prolonged Interpretation
Open Access
- 17 May 2021
- journal article
- research article
- Published by Frontiers Media SA in Frontiers in Pediatrics
Abstract
Objectives: To evaluate the positive threshold of PCT for neonates of Design: Retrospective and bicentric study from May 2016 to April 2018. Setting: Two groups were established, neonates evaluated for PCT at birth (CordPCT) and within 6 h of life (delPCT). Patients: Two hundred and sixty neonates of Main Outcomes Measures: The value of the PCT positive threshold was determined for the total population and each groups thanks ROC curves. Results: The threshold level of PCT for the total population was 0.98 ng/mL. The threshold value of cordPCT group was 1.00 vs. 0.98 ng/mL for delPCT group. The area under the Receiver Operating Characteristics curve for PCT sampled in delPCT group was significantly higher than in cordPCT group (0.94 compared to 0.75). Conclusions: The threshold level of PCT was higher in this cohort of neonates of <32 weeks of gestation compared to the value generally described for term neonates. The secondary sampling PCT level seems to be usable in screening algorithm for early-onset neonatal sepsis.This publication has 38 references indexed in Scilit:
- Early and late onset sepsis in very-low-birth-weight infants from a large group of neonatal intensive care unitsEarly Human Development, 2012
- Prolonged Initial Empirical Antibiotic Treatment is Associated with Adverse Outcomes in Premature InfantsThe Journal of Pediatrics, 2011
- Procalcitonin for diagnosis of infection and guide to antibiotic decisions: past, present and futureBMC Medicine, 2011
- Umbilical cord blood procalcitonin level in early neonatal infections: a 4-year university hospital cohort studyEuropean Journal of Clinical Microbiology & Infectious Diseases, 2011
- Use of Procalcitonin-Guided Decision-Making to Shorten Antibiotic Therapy in Suspected Neonatal Early-Onset Sepsis: Prospective Randomized Intervention TrialNeonatology, 2009
- Procalcitonin in preterm infants during the first few days of life: introducing an age related nomogramArchives of Disease in Childhood: Fetal & Neonatal, 2006
- Newer approaches to the diagnosis of early onset neonatal sepsisArchives of Disease in Childhood: Fetal & Neonatal, 2005
- Umbilical cord blood procalcitonin and C reactive protein concentrations as markers for early diagnosis of very early onset neonatal infectionArchives of Disease in Childhood: Fetal & Neonatal, 2005
- Early-onset sepsis in very low birth weight neonates: A report from the National Institute of Child Health and Human Development Neonatal Research NetworkThe Journal of Pediatrics, 1996