Choroid plexus and the blood–cerebrospinal fluid barrier in disease
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Open Access
- 6 May 2020
- journal article
- review article
- Published by Springer Science and Business Media LLC in Fluids and Barriers of the CNS
- Vol. 17 (1), 1-29
- https://doi.org/10.1186/s12987-020-00196-2
Abstract
The choroid plexus (CP) forming the blood–cerebrospinal fluid (B-CSF) barrier is among the least studied structures of the central nervous system (CNS) despite its clinical importance. The CP is an epithelio-endothelial convolute comprising a highly vascularized stroma with fenestrated capillaries and a continuous lining of epithelial cells joined by apical tight junctions (TJs) that are crucial in forming the B-CSF barrier. Integrity of the CP is critical for maintaining brain homeostasis and B-CSF barrier permeability. Recent experimental and clinical research has uncovered the significance of the CP in the pathophysiology of various diseases affecting the CNS. The CP is involved in penetration of various pathogens into the CNS, as well as the development of neurodegenerative (e.g., Alzheimer´s disease) and autoimmune diseases (e.g., multiple sclerosis). Moreover, the CP was shown to be important for restoring brain homeostasis following stroke and trauma. In addition, new diagnostic methods and treatment of CP papilloma and carcinoma have recently been developed. This review describes and summarizes the current state of knowledge with regard to the roles of the CP and B-CSF barrier in the pathophysiology of various types of CNS diseases and sets up the foundation for further avenues of research.Keywords
Funding Information
- Ministerstvo Školství, Mládeže a Tělovýchovy (CZ.02.2.69/0.0/0.0/16_027/0008360, ROZV/23/LF14/2019)
- Masarykova Univerzita (MUNI/A/1086/2018, MUNI/A/0975/2019)
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