Evaluation of Quality of Life in Patients with Chronic Leg Wounds: Can Platelet-rich Plasma Therapy Help?
Open Access
- 10 June 2020
- journal article
- Published by Vilnius University Press in Lietuvos chirurgija
- Vol. 19 (1-2), 42-50
- https://doi.org/10.15388/lietchirur.2020.19.24
Abstract
Aim. The aim of the study was to evaluate and compare the quality of life (QoL) using platelet-rich plasma gel (PRP) and conventional treatment of chronic leg wounds. Methods. Randomized clinical trial was carried out in Hospital of Lithuanian University of Health Sciences Kaunas Clinics during 2014–2018. Patients (n = 69) included in the study were randomly grouped into 2 groups: 1) PRP, 2) Control. SF-36 questionnaire was used to evaluate QoL, visual analog scale was used to evaluate persistent pain associated with ulcer and wound exudate volume was also evaluated. Statistical analysis were performed with SPSS 23.0 package. Results. Patients in PRP group at the end of the treatment rated their QoL over control group patients (p < 0.05). Wound associated pain (PRP – 1.54; control – 2.85; p = 0.015) and pain associated sleep disturbance (p < 0.001) was lower in PRP group patients. Wound exudate volume was lower in PRP group patients at the end of the treatment (p < 0.05). Conclusion. The treatment with PRP is associated with less wound associated pain, less-common sleep disturbance, reduced wound secretion and improved quality of life compared to conventional treatment.Keywords
This publication has 19 references indexed in Scilit:
- Effectiveness of autologous platelet-rich plasma gel in the treatment of hard-to-heal leg ulcers: a randomised control trialJournal of Wound Care, 2019
- Psychosocial Aspects in Patients With Chronic Leg UlcersWOUNDS: A Compendium of Clinical Research and Practice, 2017
- Platelet biology and the rationale of PRP therapy in chronic woundsEuropean Journal of Plastic Surgery, 2017
- Quality of life in patients with leg ulcers or skin lesions – a pilot studyAdvances in Dermatology and Allergology, 2015
- Platelet Rich Plasma (PRP) Biotechnology: Concepts and Therapeutic Applications in Orthopedics and Sports MedicinePublished by IntechOpen ,2012
- Treatment of Diabetic Foot Ulcers Using a Blood Bank Platelet ConcentratePlastic and Reconstructive Surgery, 2010
- Human skin wounds: A major and snowballing threat to public health and the economyWound Repair and Regeneration, 2009
- Effectiveness of autologous preparation rich in growth factors for the treatment of chronic cutaneous ulcersJournal of Biomedical Materials Research Part B: Applied Biomaterials, 2007
- Prevalence of Lower-Limb Ulceration: A Systematic Review of Prevalence StudiesAdvances in Skin & Wound Care, 2003
- Venous and non-venous leg ulcers: Clinical history and appearance in a population studyBritish Journal of Surgery, 1994