Clinical periodontal and dental findings in liver transplant patients: a systematic review and meta-analysis
- 24 January 2020
- journal article
- review article
- Published by Springer Science and Business Media LLC in British Dental Journal
- Vol. 228 (2), 108-116
- https://doi.org/10.1038/s41415-020-1196-4
Abstract
Objectives This systematic review aimed to investigate the oral health of post-liver transplant recipients (postLTx), in terms of dental and periodontal clinical results. Data sources Pubmed/MEDLINE and Cochrane Library databases were searched electronically. Data selection Prospective, cross-sectional and case-control studies comparing periodontal and dental health of postLTx patients with healthy and/or pre-liver transplant patients. Data extraction This was performed independently by two authors. Quality assessment was done by using tools from the National Heart, Lung, and Blood Institute. Data synthesis Nine studies were eligible for inclusion in the systematic review. A meta-analysis was performed on gingival inflammation, expressed by scores, on four studies including healthy controls. The gingival index scores were significantly higher in postLTx patients compared with healthy controls (p 2 = 99.5%). Increased tendency of gingival enlargement was noticed in postLTx patients, especially after immunosuppression with Cyclosporine A. Controversial results were reported for the prevalence of caries in postLTx recipients, but there seems to be an increase. Conclusion The results suggest that patients with liver transplants, due to systemic condition and immunosuppressive therapy, exhibit a higher degree of gingival inflammation compared with unexposed patients. Prospero registration number: CRD42019121893This publication has 44 references indexed in Scilit:
- Prevalence of apical periodontitis and frequency of root canal treatments in liver transplant candidatesMedicina Oral Patología Oral y Cirugia Bucal, 2013
- Oral Disease Burden and Utilization of Dental Care Patterns Among Pediatric Solid Organ Transplant RecipientsJournal of Public Health Dentistry, 2009
- Statin use is associated with fewer periodontal lesions: A retrospective studyBMC Oral Health, 2008
- Periodontal Changes in Liver Cirrhosis and Post‐Transplantation Patients. I: Clinical FindingsThe Journal of Periodontology, 2001
- Aetiology and Pathophysiology of Chronic Liver DisordersDrugs, 1990
- Cyclosporine: A Review and Its Specific Use in Liver TransplantationMayo Clinic Proceedings, 1989
- The Plaque Control RecordThe Journal of Periodontology, 1972
- The Gingival Index, the Plaque Index and the Retention Index SystemsThe Journal of Periodontology, 1967
- Periodontal Disease in Pregnancy II. Correlation Between Oral Hygiene and Periodontal ConditionActa Odontologica Scandinavica, 1964