Tissue-Specific Accumulation, Sexual Difference, and Maternal Transfer of Chlorinated Paraffins in Black-Spotted Frogs
Open Access
- 12 April 2019
- journal article
- research article
- Published by American Chemical Society (ACS) in Environmental Science & Technology
- Vol. 53 (9), 4739-4746
- https://doi.org/10.1021/acs.est.8b06350
Abstract
The restriction on usage of short-chain chlorinated paraffins (SCCPs) under Stockholm Convention may promote the production and application of medium chain chlorinated paraffins (MCCPs) and long chain chlorinated paraffins (LCCPs) as substitutes. This study focused on the tissue-specific exposure to SCCPs, MCCPs, and LCCPs in black-spotted frog, a prevalent amphibian species in the Yangtze River Delta, China. The total CP concentrations in frog liver, muscle, and egg samples ranged of 35-1200, 6.3-97, and 6.8-300 ng/g wet weight (ww), respectively. Livers and eggs contained primary SCCPs (on average 78%) while MCCPs (43%) together with SCCPs (41%) were dominant in muscles. A significantly negative correlation was observed between hepatosomatic index and CPs concentration in liver (p < 0.01), indicating that CP exposure may lower survival rates of frogs by suppressing the energy storage in liver. Additionally, maternal transfer, an important uptake pathway for CPs, was evaluated for the first time by calculating the ratios of CP levels in eggs to those in their paired liver tissues. The ratio of egg to liver for CP congener groups raised with the increasing of log Kow values, indicating mother to egg transport of CPs was related to the lipophilicity of the chemicals.Funding Information
- Vetenskapsr?det (639-2013-6913)
- National Natural Science Foundation of China (21876136, 41401571)
This publication has 62 references indexed in Scilit:
- Brominated and chlorinated flame retardants in liver of Greenland shark (Somniosus microcephalus)Chemosphere, 2013
- Distribution and Trophic Transfer of Short-Chain Chlorinated Paraffins in an Aquatic Ecosystem Receiving Effluents from a Sewage Treatment PlantEnvironmental Science & Technology, 2011
- Occurrence, fate and analysis of polychlorinated n-alkanes in the environmentTrAC Trends in Analytical Chemistry, 2009
- Chlorinated paraffins: A review of analysis and environmental occurrenceEnvironment International, 2006
- Sublethal Toxic Effects and Induction of gGutathione S-transferase by Short-Chain Chlorinated Paraffins (SCCPs) and C-12 alkane (dodecane) in Xenopus laevis Frog EmbryosActa Veterinaria Brno, 2006
- Using Fish Biomarkers to Monitor Improvements in Environmental QualityJournal of Aquatic Animal Health, 2005
- Maternal Transfer and in Ovo Exposure of Organochlorines in Oviparous Organisms: A Model and Field VerificationEnvironmental Science & Technology, 1998
- Comparison of Reliability of log P Values for Drugs Calculated by Several Methods.CHEMICAL & PHARMACEUTICAL BULLETIN, 1994
- Effect of cadmium accumulation on serum vitellogenin levels and hepatosomatic and gonadosomatic indices of winter flounder (Pleuronectes americanus)Archives of Environmental Contamination and Toxicology, 1993
- Simple Method of Calculating Octanol/Water Partition Coefficient.CHEMICAL & PHARMACEUTICAL BULLETIN, 1992