Metabolic and functional reprogramming of myeloid-derived suppressor cells and their therapeutic control in glioblastoma
Open Access
- 11 February 2019
- journal article
- review article
- Published by Shared Science Publishers OG in Cell Stress
- Vol. 3 (2), 47-65
- https://doi.org/10.15698/cst2019.02.176
Abstract
Metabolic and functional reprogramming of myeloid-derived suppressor cells and their therapeutic control in glioblastoma – Glioblastoma, also known as glioblastoma multiforme, is the most common and deadliest form of high-grade malignant brain tumors with limited available treatments. Within the glioblastoma tumor microenvironment (TME), tumor cells, stromal cells, and infiltrating immune cells continuously interact and exchange signals through various secreted factors including cytokines, chemokines, growth factors, and metabolites. Simultaneously, they dynamically reprogram their metabolism according to environmental energy demands such as hypoxia and neo-vascularization. Such metabolic reprogramming can determine fates and functions of tumor cells as well as immune cells. Ultimately, glioma cells in the TME transform immune cells to suppress anti-tumor immune cells such as T, natural killer (NK) cells, and dendritic cells (DC), and evade immune surveillance, and even to promote (...)Keywords
This publication has 131 references indexed in Scilit:
- Targeting Tregs in Malignant Brain Cancer: Overcoming IDOFrontiers in Immunology, 2013
- Coordinated regulation of myeloid cells by tumoursNature Reviews Immunology, 2012
- Redefining the relevance of established cancer cell lines to the study of mechanisms of clinical anti-cancer drug resistanceProceedings of the National Academy of Sciences of the United States of America, 2011
- S100B attenuates microglia activation in gliomas: Possible role of STAT3 pathwayGlia, 2010
- Systemic delivery of neutralizing antibody targeting CCL2 for glioma therapyJournal of Neuro-Oncology, 2010
- HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironmentThe Journal of Experimental Medicine, 2010
- Myeloid-derived suppressor cells as regulators of the immune systemNature Reviews Immunology, 2009
- HIF1α Induces the Recruitment of Bone Marrow-Derived Vascular Modulatory Cells to Regulate Tumor Angiogenesis and InvasionCancer Cell, 2008
- The 2007 WHO Classification of Tumours of the Central Nervous SystemActa Neuropathologica, 2007
- Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell functionThe Journal of Experimental Medicine, 2006