Curcumin Complex Analogues as Near-Infrared Fluorescent Probes for Monitoring all Aβ Species in the Early Alzheimer’s Disease Model
- 14 September 2021
- journal article
- research article
- Published by American Chemical Society (ACS) in ACS Chemical Neuroscience
- Vol. 12 (19), 3683-3689
- https://doi.org/10.1021/acschemneuro.1c00419
Abstract
Aggregation of amyloid beta-peptide (A beta) is closely related to the pathology of Alzheimer's disease (AD). In this pathology, the beginning stage is characterized by excessive accumulation of A beta monomers due to imbalanced A beta in the process of clearance. The A beta peptide exists in many forms such as soluble and insoluble A beta species, both of which coexist during the progression of AD and contribute to AD pathology. Thus, probes capable of monitoring all A beta species are highly desirable. While there are several fluorescent probes for detecting insoluble A beta, it is still challenging to monitor all A beta forms by using probes. Here, we describe a near-infrared fluorescent chemical probe, termed AD-1, developed through complexation of curcumin analogues with a stabilizer, which has good photophysical properties and shows high binding to all A beta species in solution tests. Furthermore, AD-1 exhibited good blood-brain barrier penetrating ability and low cytotoxicity. More importantly, it was successfully applied to 4-month-young APP/PS1 mice imaging noninvasively.Keywords
Funding Information
- National Natural Science Foundation of China (81971677)
- Changhai Hospital of Shanghai (2019YPT002, 2020YPT002)
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