In the current pandemic, it is imperative to comprehend and advance a search forward to explore the pathogenesis of stroke in COVID-19 infected patients. In this review, we have discussed the prevalence of stroke in COVID-19 infected patients and different risk factors associated with the stroke in COVID-19. We also presented a comprehensive review on management of Stroke Patients during the COVID-19 pandemic. The COVID-19 positive patients with stroke should be treated in a designated COVID-19 health care center as per the guidelines. Study also showed that older patients with a history of cardiovascular diseases, prothrombotic state, smoking, and infection significantly had a higher likelihood of stroke incidence. The study revealed that effective treatment of COVID-19 and reduction of the inflammatory conditions may seem to be the way forward to minimize the symptomatic stroke associated with COVID-19 infection, and rehabilitation of Stroke patients should be optimal during a pandemic.