Roles of bile acids in enteric virus replication
Open Access
- 23 April 2021
- journal article
- review article
- Published by Springer Science and Business Media LLC in Animal Diseases
- Vol. 1 (1), 1-9
- https://doi.org/10.1186/s44149-021-00003-x
Abstract
Bile acids (BAs) are evolutionally conserved molecules synthesized in the liver from cholesterol to facilitating the absorption of fat-soluble nutrients. In the intestines, where enteric viruses replicate, BAs also act as signaling molecules that modulate various biological functions via activation of specific receptors and cell signaling pathways. To date, BAs present either pro-viral or anti-viral effects for the replication of enteric viruses in vivo and in vitro. In this review, we summarized current information on biosynthesis, transportation and metabolism of BAs and the role of BAs in replication of enteric caliciviruses, rotaviruses, and coronaviruses. We also discussed the application of BAs for cell culture adaptation of fastidious enteric caliciviruses and control of virus infection, which may provide novel insights into the development of antivirals and/or disinfectants for enteric viruses.Keywords
This publication has 100 references indexed in Scilit:
- Bile Acids Specifically Increase Hepatitis C Virus RNA-ReplicationPLOS ONE, 2012
- Limited Effects of Bile Acids and Small Heterodimer Partner on Hepatitis B Virus Biosynthesis In VivoJournal of Virology, 2012
- Inhibitory Effects of Bile Acids and Synthetic Farnesoid X Receptor Agonists on Rotavirus ReplicationJournal of Virology, 2011
- Bile Acids Promote HCV Replication through the EGFR/ERK Pathway in Replicon-Harboring CellsIntervirology, 2011
- Bile acid transportersJournal of Lipid Research, 2009
- Bile acids: regulation of synthesisJournal of Lipid Research, 2009
- Bile Acids Promote the Expression of Hepatitis C Virus in Replicon-Harboring CellsJournal of Virology, 2007
- Pathogenesis of a Genogroup II Human Norovirus in Gnotobiotic PigsJournal of Virology, 2006
- Murine Norovirus: a Model System To Study Norovirus Biology and PathogenesisJournal of Virology, 2006
- The Enzymes, Regulation, and Genetics of Bile Acid SynthesisAnnual Review of Biochemistry, 2003