Verification of morphological and physical properties for the development of a lung substitute phantom using microspheres
- 1 June 2022
- journal article
- research article
- Published by AIP Publishing in Review of Scientific Instruments
- Vol. 93 (6), 064101
- https://doi.org/10.1063/5.0090471
Abstract
This paper proposes a new concept of phantom development, along with the utilization of new materials that can reproduce lung morphology and density. A lung substitute phantom using microspheres was fabricated; then, its dosimetric utility in radiotherapy was investigated, during which the density was adjusted to closely resemble the morphology of the actual human lung. Microspheres were used to reproduce alveoli, which are the main components of the lung. By changing the ratio of urethane, which is commonly used in soft tissue phantoms, to microspheres, we reproduced the density change of the lungs due to respiration. Here, we fabricated two slab-like lung substitutes to emulate commercially used phantoms. Although there is room for improvement in terms of practicality, the substitutes were easy to fabricate. Microscopic observation of the cut surface of the phantoms showed that the morphology of the phantoms mimicked the alveoli more faithfully than commercial phantoms. Furthermore, to compensate for the energy-independent mass attenuation and mass collision inhibition ability required by the tissue substitute phantom, we examined the physical properties of the phantom and confirmed that there was negligible energy dependence. Published under an exclusive license by AIP PublishingFunding Information
- Japan Society for the Promotion of Science (20K16765, 21K07599)
This publication has 14 references indexed in Scilit:
- Modeling lung deformation: A combined deformable image registration method with spatially varying Young's modulus estimatesMedical Physics, 2013
- Toward efficient biomechanical-based deformable image registration of lungs for image-guided radiotherapyPhysics in Medicine & Biology, 2011
- Results of a Multi-Institution Deformable Registration Accuracy Study (MIDRAS)International Journal of Radiation Oncology*Biology*Physics, 2010
- Phantom investigation of 3D motion-dependent volume aliasing during CT simulation for radiation therapy planningRadiation Oncology, 2007
- Accuracy of finite element model‐based multi‐organ deformable image registrationMedical Physics, 2005
- The Number of Alveoli in the Human LungAmerican Journal of Respiratory and Critical Care Medicine, 2004
- Functional polymer microspheresProgress in Polymer Science, 2000
- The calibration of CT Hounsfield units for radiotherapy treatment planningPhysics in Medicine & Biology, 1996
- Photon mass attenuation and energy-absorption coefficientsThe International Journal of Applied Radiation and Isotopes, 1982
- Elasticity Properties of Lung Parenchyma Derived from Experimental Distortion DataBiophysical Journal, 1975