Square Wave Anodic Voltammetric Determination of Antidiabetic Drug Linagliptin in The Dosage Form and Biological Fluids by Microparticles Copper Pencil Graphite Electrode
- 25 February 2021
- journal article
- research article
- Published by Egypts Presidential Specialized Council for Education and Scientific Research in Egyptian Journal of Chemistry
- Vol. 64 (6), 3121-3130
- https://doi.org/10.21608/ejchem.2021.48845.2999
Abstract
A new simple, cheap, and rapid method to increase the sensitivity of pencil graphite electrode (PGE) to determine Linagliptin (LNG) was developed by modified PGE with copper microparticles (Cu-PGE). The disposable modified sensor electrode's preparation depended on the electrodeposition of Cu-microparticles on the PGE that can be applied for determined LNG by complexed it with Cu+2 ions and measure the LNG-Cu complex onto the Cu-PGE improved. The preparation of this modified electrode is easy, simple, and cheap, and has high sensitivity. The modified electrode detected the LNG in the LNG-Cu complex range from 47.25 - 283.53 ng mL-1 with detection and quantitative limits of 6.0 and 20.0 ng mL-1, respectively, with a correlation coefficient of 0.9995. The proposed method was applied with success to determined LNG in the dosage form, spiked urine, and spiked plasma samples; additionally, the obtained modified electrode was put in comparison with the reported electrodes.Keywords
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