Phytoantioxidant Functionalized Nanoparticles: A Green Approach to Combat Nanoparticle-Induced Oxidative Stress
Open Access
- 26 October 2021
- journal article
- review article
- Published by Hindawi Limited in Oxidative Medicine and Cellular Longevity
- Vol. 2021, 1-20
- https://doi.org/10.1155/2021/3155962
Abstract
Nanotechnology is gaining significant attention, with numerous biomedical applications. Silver in wound dressings, copper oxide and silver in antibacterial preparations, and zinc oxide nanoparticles as a food and cosmetic ingredient are common examples. However, adverse effects of nanoparticles in humans and the environment from extended exposure at varied concentrations have yet to be established. One of the drawbacks of employing nanoparticles is their tendency to cause oxidative stress, a significant public health concern with life-threatening consequences. Cardiovascular, renal, and respiratory problems and diabetes are among the oxidative stress-related disorders. In this context, phytoantioxidant functionalized nanoparticles could be a novel and effective alternative. In addition to performing their intended function, they can protect against oxidative damage. This review was designed by searching through various websites, books, and articles found in PubMed, Science Direct, and Google Scholar. To begin with, oxidative stress, its related diseases, and the mechanistic basis of oxidative damage caused by nanoparticles are discussed. One of the main mechanisms of action of nanoparticles was unearthed to be oxidative stress, which limits their use in humans. Secondly, the role of phytoantioxidant functionalized nanoparticles in oxidative damage prevention is critically discussed. The parameters for the characterization of nanoparticles were also discussed. The majority of silver, gold, iron, zinc oxide, and copper nanoparticles produced utilizing various plant extracts were active free radical scavengers. This potential is linked to several surface fabricated phytoconstituents, such as flavonoids and phenols. These phytoantioxidant functionalized nanoparticles could be a better alternative to nanoparticles prepared by other existing approaches.Keywords
Funding Information
- MH CZ-DRO (00179906)
This publication has 193 references indexed in Scilit:
- High Correlation of 2,2-diphenyl-1-picrylhydrazyl (DPPH) Radical Scavenging, Ferric Reducing Activity Potential and Total Phenolics Content Indicates Redundancy in Use of All Three Assays to Screen for Antioxidant Activity of Extracts of Plants from the Malaysian RainforestAntioxidants, 2013
- Oxidative Stress and Antioxidant DefenseWorld Allergy Organization Journal, 2012
- ER stress activates the NLRP3 inflammasome via an UPR-independent pathwayCell Death & Disease, 2012
- Silver nanoparticles: Evaluation of DNA damage, toxicity and functional impairment in human mesenchymal stem cellsToxicology Letters, 2011
- Copper oxide nanoparticles induce oxidative stress and cytotoxicity in airway epithelial cellsToxicology in Vitro, 2009
- Oxidative stress-dependent toxicity of silver nanoparticles in human hepatoma cellsToxicology in Vitro, 2009
- Anti-proliferative activity of silver nanoparticlesBMC Cell Biology, 2009
- Cell and molecular mechanisms of keratinocyte function stimulated by insulin during wound healingBMC Cell Biology, 2009
- DNA damage response to different surface chemistry of silver nanoparticles in mammalian cellsToxicology and Applied Pharmacology, 2008
- Cytotoxicity of Colloidal CdSe and CdSe/ZnS NanoparticlesNano Letters, 2004