Neural Correlates of Weight Gain With Olanzapine

Abstract

Individuals with psychiatric disorders have significantly higher mortality rates than the general population, with an average of 22 lost potential years of life.¹ Heart disease is the leading cause of death in the mentally ill population,¹ and obesity is a key modifiable risk factor for heart disease and other co-occurring conditions such as diabetes mellitus.² Iatrogenic obesity caused by antipsychotic medications, especially the commonly prescribed atypical antipsychotics, negatively impacts medication compliance^3,4; predisposes patients to cardiovascular illness, type 2 diabetes, and metabolic dysregulations; and increases the rate of death from all causes.^5-10