Genetic stratification of depression in UK Biobank
Open Access
- 24 May 2020
- journal article
- research article
- Published by Springer Science and Business Media LLC in Translational Psychiatry
- Vol. 10 (1), 1-8
- https://doi.org/10.1038/s41398-020-0848-0
Abstract
Depression is a common and clinically heterogeneous mental health disorder that is frequently comorbid with other diseases and conditions. Stratification of depression may align sub-diagnoses more closely with their underling aetiology and provide more tractable targets for research and effective treatment. In the current study, we investigated whether genetic data could be used to identify subgroups within people with depression using the UK Biobank. Examination of cross-locus correlations were used to test for evidence of subgroups using genetic data from seven other complex traits and disorders that were genetically correlated with depression and had sufficient power (>0.6) for detection. We found no evidence for subgroups within depression for schizophrenia, bipolar disorder, attention deficit/hyperactivity disorder, autism spectrum disorder, anorexia nervosa, inflammatory bowel disease or obesity. This suggests that for these traits, genetic correlations with depression were driven by pleiotropic genetic variants carried by everyone rather than by a specific subgroup.Funding Information
- Wellcome Trust (213674/Z/18/Z, 104036/Z/14/Z)
- Brain and Behavior Research Foundation (27404)
- RCUK | Medical Research Council (MR/S0151132, MR/N015746/1)
- Department of Health | National Health and Medical Research Council (1078901, 1087889)
This publication has 36 references indexed in Scilit:
- Genetic stratification of depression by neuroticism: revisiting a diagnostic traditionPsychological Medicine, 2019
- Using Passive Smartphone Sensing for Improved Risk Stratification of Patients With Depression and Diabetes: Cross-Sectional Observational StudyJMIR mHealth and uHealth, 2019
- Genome-wide meta-analyses of stratified depression in Generation Scotland and UK BiobankTranslational Psychiatry, 2018
- Moving forward: how depression heterogeneity hinders progress in treatment and researchExpert Review of Neurotherapeutics, 2017
- Polygenic dissection of major depression clinical heterogeneityMolecular Psychiatry, 2015
- Major Depression in the National Comorbidity Survey–Adolescent Supplement: Prevalence, Correlates, and TreatmentJournal of the American Academy of Child & Adolescent Psychiatry, 2014
- How many different ways do patients meet the diagnostic criteria for major depressive disorder?Comprehensive Psychiatry, 2014
- Prevalence, associations, and adequacy of treatment of major depression in patients with cancer: a cross-sectional analysis of routinely collected clinical dataThe Lancet Psychiatry, 2014
- Depression and cardiovascular disease: a clinical reviewEuropean Heart Journal, 2013
- Genetic Epidemiology of Major Depression: Review and Meta-AnalysisAmerican Journal of Psychiatry, 2000