Andrographis paniculata (Acanthaceae), a potential medicinal plant, distributed in waste lands, open forests in India. A. paniculata is used in the treatment of typhoid, snake bite, scorpion sting, malaria and cancer. The acetone, chloroform and aqueous extracts were evaluated for its anthelmintic activity against adult earth worms (Phertima prosthuma). Three concentrations (10, 50 and 100 mg/ml) of each extract were which involved the determination of time of paralysis and time of death of the test worms. It was found that the acetone and aqueous fraction of Andrographis paniculata of was proved to be one of the best alternative cum effective herbal remedy to control helminthic infections.