Ruxolitinib for Chronic Graft-versus-Host Disease

Abstract

To the Editor: Zeiser et al. (July 15 issue)¹ report a significantly better overall response in patients treated with ruxolitinib for glucocorticoid-refractory chronic graft-versus-host disease (GVHD), as they did 1 year ago for acute GVHD.² The authors conclude that ruxolitinib was superior to control therapy, with no new safety signals. The data fail to convince. The authors describe chronic GVHD as “a leading cause…of nonrelapse-associated death.” However, overall survival did not differ substantially between the groups after half a year of treatment, with no fewer deaths from GVHD in the ruxolitinib group. Furthermore, the primary end point of overall response . . .