Genetically Encoded Elastin‐Like Polypeptides for Drug Delivery
- 3 June 2021
- journal article
- review article
- Published by Wiley in Advanced Healthcare Materials
- Vol. 10 (13), 2100209
- https://doi.org/10.1002/adhm.202100209
Abstract
Elastin-like polypeptides (ELPs) are thermally responsive biopolymers that consist of a repeated amino acid motif derived from human tropoelastin. These peptides exhibit temperature-dependent phase behavior that can be harnessed to produce stimuli-responsive biomaterials, such as nanoparticles or injectable drug delivery depots. As ELPs are genetically encoded, the properties of ELP-based biomaterials can be controlled with a precision that is unattainable with synthetic polymers. Unique ELP architectures, such as spherical or rod-like micelles or injectable coacervates, can be designed by manipulating the ELP amino acid sequence and length. ELPs can be loaded with drugs to create controlled, intelligent drug delivery systems. ELPs are biodegradable, nonimmunogenic, and tolerant of therapeutic additives. These qualities make ELPs exquisitely well-suited to address current challenges in drug delivery and have spurred the development of ELP-based therapeutics to treat diseases—such as cancer and diabetes—and to promote wound healing. This review focuses on the use of ELPs in drug delivery systems.This publication has 102 references indexed in Scilit:
- Tunable Self-Assembly of Genetically Engineered Silk–Elastin-like Protein PolymersBiomacromolecules, 2011
- Biomaterials derived from silk–tropoelastin protein systemsBiomaterials, 2010
- Silk-Elastin-like Hydrogel Improves the Safety of Adenovirus-Mediated Gene-Directed Enzyme−Prodrug TherapyMolecular Pharmaceutics, 2010
- Silk‐elastinlike protein polymers improve the efficacy of adenovirus thymidine kinase enzyme prodrug therapy of head and neck tumorsThe Journal of Gene Medicine, 2010
- Injectable intratumoral depot of thermally responsive polypeptide–radionuclide conjugates delays tumor progression in a mouse modelJournal of Controlled Release, 2010
- Silk-elastinlike recombinant polymers for gene therapy of head and neck cancer: From molecular definition to controlled gene expressionJournal of Controlled Release, 2009
- Self-assembling chimeric polypeptide–doxorubicin conjugate nanoparticles that abolish tumours after a single injectionNature Materials, 2009
- Nanoparticles evading the reticuloendothelial system: Role of the supported bilayerBiochimica et Biophysica Acta (BBA) - Biomembranes, 2009
- Silk-Elastinlike Protein Polymer Hydrogels for Localized Adenoviral Gene Therapy of Head and Neck TumorsBiomacromolecules, 2009
- Influence of the Amino-Acid Sequence on the Inverse Temperature Transition of Elastin-Like PolymersBiophysical Journal, 2009